O75170: Serine/threonine-protein phosphatase 6 regulatory subunit 2

General Information

Protein names	- Serine/threonine-protein phosphatase 6 regulatory subunit 2 - SAPS domain family member 2
Gene names	PPP6R2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75170

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Isoform 3 of Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Isoform 4 of Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Isoform 5 of Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Isoform 6 of Serine/threonine-protein phosphatase 6 regulatory subunit 2

Sequence View

        10         20         30         40         50         60
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
        70         80         90        100        110        120
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
       130        140        150        160        170        180
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
       190        200        210        220        230        240
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
       250        260        270        280        290        300
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
       310        320        330        340        350        360
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
       370        380        390        400        410        420
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
       430        440        450        460        470        480
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
       490        500        510        520        530        540
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
       550        560        570        580        590        600
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
       610        620        630        640        650        660
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
       670        680        690        700        710        720
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
       730        740        750        760        770        780
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
       790        800        810        820        830        840
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
       850        860        870        880        890        900
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
       910        920        930        940        950        960
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA

ALNGPV         10         20         30         40         50         60
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
        70         80         90        100        110        120
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
       130        140        150        160        170        180
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
       190        200        210        220        230        240
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
       250        260        270        280        290        300
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
       310        320        330        340        350        360
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
       370        380        390        400        410        420
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
       430        440        450        460        470        480
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
       490        500        510        520        530        540
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
       550        560        570        580        590        600
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
       610        620        630        640        650        660
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
       670        680        690        700        710        720
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
       730        740        750        760        770        780
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
       790        800        810        820        830        840
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
       850        860        870        880        890        900
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
       910        920        930        940        950        960
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA

ALNGPV         10         20         30         40         50         60
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
        70         80         90        100        110        120
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
       130        140        150        160        170        180
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
       190        200        210        220        230        240
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
       250        260        270        280        290        300
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
       310        320        330        340        350        360
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
       370        380        390        400        410        420
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
       430        440        450        460        470        480
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
       490        500        510        520        530        540
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
       550        560        570        580        590        600
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
       610        620        630        640        650        660
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
       670        680        690        700        710        720
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
       730        740        750        760        770        780
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
       790        800        810        820        830        840
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
       850        860        870        880        890        900
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
       910        920        930        940        950        960
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA

ALNGPV         10         20         30         40         50         60
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
        70         80         90        100        110        120
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
       130        140        150        160        170        180
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
       190        200        210        220        230        240
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
       250        260        270        280        290        300
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
       310        320        330        340        350        360
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
       370        380        390        400        410        420
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
       430        440        450        460        470        480
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
       490        500        510        520        530        540
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
       550        560        570        580        590        600
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
       610        620        630        640        650        660
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
       670        680        690        700        710        720
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
       730        740        750        760        770        780
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
       790        800        810        820        830        840
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
       850        860        870        880        890        900
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
       910        920        930        940        950        960
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA

ALNGPV         10         20         30         40         50         60
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
        70         80         90        100        110        120
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
       130        140        150        160        170        180
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
       190        200        210        220        230        240
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
       250        260        270        280        290        300
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
       310        320        330        340        350        360
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
       370        380        390        400        410        420
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
       430        440        450        460        470        480
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
       490        500        510        520        530        540
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
       550        560        570        580        590        600
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
       610        620        630        640        650        660
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
       670        680        690        700        710        720
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
       730        740        750        760        770        780
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
       790        800        810        820        830        840
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
       850        860        870        880        890        900
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
       910        920        930        940        950        960
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA

ALNGPV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O75170-1-unknown	MFWKFD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75170-1-unknown	MFWKFD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85874
O75170-1-unknown	MFWKFD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85875
O75170-1-unknown	MFWKFD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85876
O75170-1-unknown	MFWKFD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85877
O75170-1-unknown	MFWKFD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85878
O75170-611-unknown	EDSPSA...	611	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10911
O75170-611-unknown	EDSPSA...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154064
O75170-611-unknown	EDSPSA...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154386
O75170-611-unknown	EDSPSA...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154387
O75170-611-unknown	EDSPSA...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154395
O75170-611-unknown	EDSPSA...	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154762
O75170-818-unknown	LASDSS...	818	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13787
O75170-818-unknown	LASDSS...	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156298
O75170-818-unknown	LASDSS...	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156441
O75170-818-unknown	LASDSS...	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156443
O75170-818-unknown	LASDSS...	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156444
O75170-818-unknown	LASDSS...	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156536

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NIDADE	610	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10911
...NIDADE	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137483
...NIDADE	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137807
...NIDADE	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137808
...NIDADE	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137816
...NIDADE	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138188
...RKAPLL	817	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13787
...LNGPV	966	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LNGPV	966	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81496
...LNGPV	966	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81494
...LNGPV	966	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81493
...LNGPV	966	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81495

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	610	DADE.\|.EDSP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	817	APLL.\|.LASD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)