O75390: Citrate synthase, mitochondrial

General Information

Protein names	- Citrate synthase, mitochondrial - 2.3.3.1 - Citrate (Si)-synthase
Gene names	CS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75390

9 N-termini

15 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALLTAAARL LGTKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT FRQQHGKTVV
        70         80         90        100        110        120
GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE CQKLLPKAKG GEEPLPEGLF
       130        140        150        160        170        180
WLLVTGHIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AVTALNSESN
       190        200        210        220        230        240
FARAYAQGIS RTKYWELIYE DSMDLIAKLP CVAAKIYRNL YREGSGIGAI DSNLDWSHNF
       250        260        270        280        290        300
TNMLGYTDHQ FTELTRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL
       310        320        330        340        350        360
HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ
       370        380        390        400        410        420
REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY
       430        440        450        460
TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTEGLMKF VDSKSG

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 15 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75390-20-	VLAARH...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75390-26-unknown	ASASST...	26		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75390-26-unknown	ASASST...	26		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
O75390-26-	ASASST...	26		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75390-27-	SASSTN...	27		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75390-28-unknown	ASSTNL...	28	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446779
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450312
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449025
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450101
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449427
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448409
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449753
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447346
O75390-67-unknown	MMYGGM...	67	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448166
O75390-83-	SVLDPD...	83		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75390-328-unknown	LRDYIW...	328	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449080
O75390-328-unknown	LRDYIW...	328	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75390-328-unknown	LRDYIW...	328	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O75390-351-unknown	RKTDPR...	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8443

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IPTEEQ	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448166
...AKRAAL	146	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447346
...SQLSAA	170	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447948
...ALNSES	178	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448172
...NSESNF	180	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449753
...SNFARA	183	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448409
...ARAYAQ	186	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449427
...ISRTKY	193	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447442
...SMDLIA	206	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450101
...IAKLPC	210	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450312
...IAKLPC	210	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449025
...KLPCVA	212	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450403
...CVAAKI	215	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448667
...GHAVLR	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8443
...DSKSG	466		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSKSG	466		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DSKSG	466	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DSKSG	466		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSKSG	466		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CTRB2_HUMAN	350	AVLR.\|.RKTD	inferred from experiment	unknown	MEROPS	Eggerer H	Lill U et al.:Hysteretic behaviour of citrate... (S01.152)	6381053,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)