O75400: Pre-mRNA-processing factor 40 homolog A

General Information

Protein names	- Pre-mRNA-processing factor 40 homolog A - Fas ligand-associated factor 1 - Formin-binding protein 11 - Formin-binding protein 3 - Huntingtin yeast partner A - Huntingtin-interacting protein 10 - HIP-10 - Huntingtin-interacting protein A - Renal carcinoma antigen NY-REN-6
Gene names	PRPF40A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75400

14 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pre-mRNA-processing factor 40 homolog A - Isoform 3 of Pre-mRNA-processing factor 40 homolog A - Isoform 5 of Pre-mRNA-processing factor 40 homolog A

Sequence View

        10         20         30         40         50         60
MRPGTGAERG GLMVSEMESH PPSQGPGDGE RRLSGSSLCS GSWVSADGFL RRRPSMGHPG
        70         80         90        100        110        120
MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM PGMMSSVMPG MMMSHMSQAS
       130        140        150        160        170        180
MQPALPPGVN SMDVAAGTAS GAKSMWTEHK SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ
       190        200        210        220        230        240
LLSKCPWKEY KSDSGKPYYY NSQTKESRWA KPKELEDLEG YQNTIVAGSL ITKSNLHAMI
       250        260        270        280        290        300
KAEESSKQEE CTTTSTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA AAAANANAST
       310        320        330        340        350        360
SASNTVSGTV PVVPEPEVTS IVATVVDNEN TVTISTEEQA QLTSTPAIQD QSVEVSSNTG
       370        380        390        400        410        420
EETSKQETVA DFTPKKEEEE SQPAKKTYTW NTKEEAKQAF KELLKEKRVP SNASWEQAMK
       430        440        450        460        470        480
MIINDPRYSA LAKLSEKKQA FNAYKVQTEK EEKEEARSKY KEAKESFQRF LENHEKMTST
       490        500        510        520        530        540
TRYKKAEQMF GEMEVWNAIS ERDRLEIYED VLFFLSKKEK EQAKQLRKRN WEALKNILDN
       550        560        570        580        590        600
MANVTYSTTW SEAQQYLMDN PTFAEDEELQ NMDKEDALIC FEEHIRALEK EEEEEKQKSL
       610        620        630        640        650        660
LRERRRQRKN RESFQIFLDE LHEHGQLHSM SSWMELYPTI SSDIRFTNML GQPGSTALDL
       670        680        690        700        710        720
FKFYVEDLKA RYHDEKKIIK DILKDKGFVV EVNTTFEDFV AIISSTKRST TLDAGNIKLA
       730        740        750        760        770        780
FNSLLEKAEA REREREKEEA RKMKRKESAF KSMLKQAAPP IELDAVWEDI RERFVKEPAF
       790        800        810        820        830        840
EDITLESERK RIFKDFMHVL EHECQHHHSK NKKHSKKSKK HHRKRSRSRS GSDSDDDDSH
       850        860        870        880        890        900
SKKKRQRSES RSASEHSSSA ESERSYKKSK KHKKKSKKRR HKSDSPESDA EREKDKKEKD
       910        920        930        940        950
RESEKDRTRQ RSESKHKSPK KKTGKDSGNW DTSGSELSEG ELEKRRRTLL EQLDDDQ         10         20         30         40         50         60
MRPGTGAERG GLMVSEMESH PPSQGPGDGE RRLSGSSLCS GSWVSADGFL RRRPSMGHPG
        70         80         90        100        110        120
MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM PGMMSSVMPG MMMSHMSQAS
       130        140        150        160        170        180
MQPALPPGVN SMDVAAGTAS GAKSMWTEHK SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ
       190        200        210        220        230        240
LLSKCPWKEY KSDSGKPYYY NSQTKESRWA KPKELEDLEG YQNTIVAGSL ITKSNLHAMI
       250        260        270        280        290        300
KAEESSKQEE CTTTSTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA AAAANANAST
       310        320        330        340        350        360
SASNTVSGTV PVVPEPEVTS IVATVVDNEN TVTISTEEQA QLTSTPAIQD QSVEVSSNTG
       370        380        390        400        410        420
EETSKQETVA DFTPKKEEEE SQPAKKTYTW NTKEEAKQAF KELLKEKRVP SNASWEQAMK
       430        440        450        460        470        480
MIINDPRYSA LAKLSEKKQA FNAYKVQTEK EEKEEARSKY KEAKESFQRF LENHEKMTST
       490        500        510        520        530        540
TRYKKAEQMF GEMEVWNAIS ERDRLEIYED VLFFLSKKEK EQAKQLRKRN WEALKNILDN
       550        560        570        580        590        600
MANVTYSTTW SEAQQYLMDN PTFAEDEELQ NMDKEDALIC FEEHIRALEK EEEEEKQKSL
       610        620        630        640        650        660
LRERRRQRKN RESFQIFLDE LHEHGQLHSM SSWMELYPTI SSDIRFTNML GQPGSTALDL
       670        680        690        700        710        720
FKFYVEDLKA RYHDEKKIIK DILKDKGFVV EVNTTFEDFV AIISSTKRST TLDAGNIKLA
       730        740        750        760        770        780
FNSLLEKAEA REREREKEEA RKMKRKESAF KSMLKQAAPP IELDAVWEDI RERFVKEPAF
       790        800        810        820        830        840
EDITLESERK RIFKDFMHVL EHECQHHHSK NKKHSKKSKK HHRKRSRSRS GSDSDDDDSH
       850        860        870        880        890        900
SKKKRQRSES RSASEHSSSA ESERSYKKSK KHKKKSKKRR HKSDSPESDA EREKDKKEKD
       910        920        930        940        950
RESEKDRTRQ RSESKHKSPK KKTGKDSGNW DTSGSELSEG ELEKRRRTLL EQLDDDQ         10         20         30         40         50         60
MRPGTGAERG GLMVSEMESH PPSQGPGDGE RRLSGSSLCS GSWVSADGFL RRRPSMGHPG
        70         80         90        100        110        120
MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM PGMMSSVMPG MMMSHMSQAS
       130        140        150        160        170        180
MQPALPPGVN SMDVAAGTAS GAKSMWTEHK SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ
       190        200        210        220        230        240
LLSKCPWKEY KSDSGKPYYY NSQTKESRWA KPKELEDLEG YQNTIVAGSL ITKSNLHAMI
       250        260        270        280        290        300
KAEESSKQEE CTTTSTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA AAAANANAST
       310        320        330        340        350        360
SASNTVSGTV PVVPEPEVTS IVATVVDNEN TVTISTEEQA QLTSTPAIQD QSVEVSSNTG
       370        380        390        400        410        420
EETSKQETVA DFTPKKEEEE SQPAKKTYTW NTKEEAKQAF KELLKEKRVP SNASWEQAMK
       430        440        450        460        470        480
MIINDPRYSA LAKLSEKKQA FNAYKVQTEK EEKEEARSKY KEAKESFQRF LENHEKMTST
       490        500        510        520        530        540
TRYKKAEQMF GEMEVWNAIS ERDRLEIYED VLFFLSKKEK EQAKQLRKRN WEALKNILDN
       550        560        570        580        590        600
MANVTYSTTW SEAQQYLMDN PTFAEDEELQ NMDKEDALIC FEEHIRALEK EEEEEKQKSL
       610        620        630        640        650        660
LRERRRQRKN RESFQIFLDE LHEHGQLHSM SSWMELYPTI SSDIRFTNML GQPGSTALDL
       670        680        690        700        710        720
FKFYVEDLKA RYHDEKKIIK DILKDKGFVV EVNTTFEDFV AIISSTKRST TLDAGNIKLA
       730        740        750        760        770        780
FNSLLEKAEA REREREKEEA RKMKRKESAF KSMLKQAAPP IELDAVWEDI RERFVKEPAF
       790        800        810        820        830        840
EDITLESERK RIFKDFMHVL EHECQHHHSK NKKHSKKSKK HHRKRSRSRS GSDSDDDDSH
       850        860        870        880        890        900
SKKKRQRSES RSASEHSSSA ESERSYKKSK KHKKKSKKRR HKSDSPESDA EREKDKKEKD
       910        920        930        940        950
RESEKDRTRQ RSESKHKSPK KKTGKDSGNW DTSGSELSEG ELEKRRRTLL EQLDDDQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75400-1-unknown	MRPGTG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75400-1-unknown	MRPGTG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86070
O75400-1-unknown	MRPGTG...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75400-1-	MRPGTG...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75400-14-unknown	VSEMES...	14		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75400-14-unknown	VSEMES...	14	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160072
O75400-14-	VSEMES...	14		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75400-14-	VSEMES...	14		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75400-114-unknown	SHMSQA...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167623
O75400-114-unknown	SHMSQA...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167622
O75400-114-	SHMSQA...	114		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75400-120-	SMQPAL...	120		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75400-120-unknown	SMQPAL...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173717
O75400-120-unknown	SMQPAL...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173716
O75400-124-unknown	ALPPGV...	124	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O75400-124-unknown	ALPPGV...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197314
O75400-124-unknown	ALPPGV...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197313
O75400-131-	SMDVAA...	131		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75400-131-unknown	SMDVAA...	131	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172659
O75400-131-unknown	SMDVAA...	131	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172658
O75400-134-unknown	VAAGTA...	134		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75400-134-unknown	VAAGTA...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161935
O75400-134-unknown	VAAGTA...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161934
O75400-134-	VAAGTA...	134		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75400-134-	VAAGTA...	134		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75400-723-unknown	SLLEKA...	723	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10946
O75400-723-unknown	SLLEKA...	723	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155829
O75400-723-unknown	SLLEKA...	723	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155903

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KLAFNS	722	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10946
...KLAFNS	722	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139281
...KLAFNS	722	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139360
...LDDDQ	957		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LDDDQ	957		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LDDDQ	957	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LDDDQ	957	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81687
...LDDDQ	957	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81688
...LDDDQ	957		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LDDDQ	957		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	722	AFNS.\|.SLLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)