O75489: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

General Information

Protein names	- NADH dehydrogenase ubiquinone] iron-sulfur protein 3, mitochondrial - 1.6.99.3 - 7.1.1.2 - Complex I-30kD - CI-30kD - NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene names	NDUFS3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75489

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR NDVAHKQLSA
        70         80         90        100        110        120
FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL RDHTNAQFKS LVDLTAVDVP
       130        140        150        160        170        180
TRQNRFEIVY NLLSLRFNSR IRVKTYTDEL TPIESAVSVF KAANWYEREI WDMFGVFFAN
       190        200        210        220        230        240
HPDLRRILTD YGFEGHPFRK DFPLSGYVEL RYDDEVKRVV AEPVELAQEF RKFDLNSPWE
       250        260
AFPVYRQPPE SLKLEAGDKK PDAK

Isoforms

- Isoform 2 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75489-37-unknown	ESAGAD...	37	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75489-38-	SAGADT...	38		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75489-38-	SAGADT...	38		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75489-38-	SAGADT...	38		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75489-57-unknown	QLSAFG...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9907

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DVAHKQ	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9907
...PVLTFL	99	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431588
...KPDAK	264	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	56	AHKQ.\|.QLSA	inferred from experiment	unknown	MEROPS	Lieberman J	Martinvalet D et al.:Granzyme A cleaves a mitochondr... (S01.135)	18485875,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)