O75717: WD repeat and HMG-box DNA-binding protein 1
Protein names | - WD repeat and HMG-box DNA-binding protein 1 - Acidic nucleoplasmic DNA-binding protein 1 - And-1 |
---|---|
Gene names | WDHD1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O75717 |
7
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC
70 80 90 100 110 120
ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI
130 140 150 160 170 180
VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF LASASCDGSV RVWQISDQTC AISWPLLQKC
190 200 210 220 230 240
NDVINAKSIC RLAWQPKSGK LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP
250 260 270 280 290 300
CGQYLAAGSI NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL
310 320 330 340 350 360
ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS KGIINDDEDD
370 380 390 400 410 420
EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE EDGQEGSIHN LPLVTSQRPF
430 440 450 460 470 480
YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN SIGIIRCYND EQDNAIDVEF HDTSIHHATH
490 500 510 520 530 540
LSNTLNYTIA DLSHEAILLA CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL
550 560 570 580 590 600
GQGWAAAATS ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG
610 620 630 640 650 660
VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML NRGLGNTWTP
670 680 690 700 710 720
ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT LPRPAVAILS FKLPYCQIAT
730 740 750 760 770 780
EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE ESTKNQATKE QQELLMKMLA LSCKLEREFR
790 800 810 820 830 840
CVELADLMTQ NAVNLAIKYA SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK
850 860 870 880 890 900
LNAGYSNTAT EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS
910 920 930 940 950 960
GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS RTTNNEKSPI
970 980 990 1000 1010 1020
IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV LSETPAICPP QNTENQRPKT
1030 1040 1050 1060 1070 1080
GFQMWLEENR SNILSDNPDF SDEADIIKEG MIRFRVLSTE ERKVWANKAK GETASEGTEA
1090 1100 1110 1120
KKRKRVVDES DETENQEEKA KENLNLSKKQ KPLDFSTNQK LSAFAFKQE
Isoforms
- Isoform 2 of WD repeat and HMG-box DNA-binding protein 1Sequence View
10 20 30 40 50 60
MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC
70 80 90 100 110 120
ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI
130 140 150 160 170 180
VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF LASASCDGSV RVWQISDQTC AISWPLLQKC
190 200 210 220 230 240
NDVINAKSIC RLAWQPKSGK LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP
250 260 270 280 290 300
CGQYLAAGSI NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL
310 320 330 340 350 360
ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS KGIINDDEDD
370 380 390 400 410 420
EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE EDGQEGSIHN LPLVTSQRPF
430 440 450 460 470 480
YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN SIGIIRCYND EQDNAIDVEF HDTSIHHATH
490 500 510 520 530 540
LSNTLNYTIA DLSHEAILLA CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL
550 560 570 580 590 600
GQGWAAAATS ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG
610 620 630 640 650 660
VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML NRGLGNTWTP
670 680 690 700 710 720
ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT LPRPAVAILS FKLPYCQIAT
730 740 750 760 770 780
EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE ESTKNQATKE QQELLMKMLA LSCKLEREFR
790 800 810 820 830 840
CVELADLMTQ NAVNLAIKYA SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK
850 860 870 880 890 900
LNAGYSNTAT EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS
910 920 930 940 950 960
GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS RTTNNEKSPI
970 980 990 1000 1010 1020
IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV LSETPAICPP QNTENQRPKT
1030 1040 1050 1060 1070 1080
GFQMWLEENR SNILSDNPDF SDEADIIKEG MIRFRVLSTE ERKVWANKAK GETASEGTEA
1090 1100 1110 1120
KKRKRVVDES DETENQEEKA KENLNLSKKQ KPLDFSTNQK LSAFAFKQE
Protein Neighborhood
Domains & Features
7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O75717-1-unknown | MPATRK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O75717-124-unknown | MDSSQQ... | 124 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94402 | |||
O75717-124-unknown | MDSSQQ... | 124 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000399349 | |||
O75717-124-unknown | MDSSQQ... | 124 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391049 | |||
O75717-338-unknown | FLNDNA... | 338 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10963 | |||
O75717-338-unknown | FLNDNA... | 338 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147180 | |||
O75717-374- | SHILED... | 374 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75717-374-unknown | SHILED... | 374 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174083 | |||
O75717-416- | SQRPFY... | 416 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75717-416- | SQRPFY... | 416 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75717-416-unknown | SQRPFY... | 416 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168291 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QISDQT | 168 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000413435 | |||
...QISDQT | 168 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113686 | |||
...SNAGDF | 337 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10963 | |||
...SNAGDF | 337 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130520 | |||
...AFKQE | 1129 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...AFKQE | 1129 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt90020 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 337 | AGDF.|.FLND | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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