O75792: Ribonuclease H2 subunit A

General Information

Protein names	- Ribonuclease H2 subunit A - RNase H2 subunit A - 3.1.26.4 - Aicardi-Goutieres syndrome 4 protein - AGS4 - RNase H(35) - Ribonuclease HI large subunit - RNase HI large subunit - Ribonuclease HI subunit A
Gene names	RNASEH2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75792

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL
        70         80         90        100        110        120
EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT
       130        140        150        160        170        180
ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI
       190        200        210        220        230        240
CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT
       250        260        270        280        290
AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75792-1-Acetylation	MDLSEL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75792-1-Acetylation	MDLSEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75792-1-Acetylation	MDLSEL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O75792-1-Acetylation	MDLSEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75792-30-unknown	VLGVDE...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13850
O75792-257-unknown	SASENQ...	257		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10965

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RKEPCV	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13850
...VIWEDS	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10965
...SATSL	299	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	29	EPCV.\|.VLGV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	256	WEDS.\|.SASE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)