O94776: Metastasis-associated protein MTA2

General Information

Protein names	- Metastasis-associated protein MTA2 - Metastasis-associated 1-like 1 - MTA1-L1 protein - p53 target protein in deacetylase complex
Gene names	MTA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O94776

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD ISSSLNSLAD
        70         80         90        100        110        120
SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT HIRGKCSVTL LNETDILSQY
       130        140        150        160        170        180
LEKEDCFFYS LVFDPVQKTL LADQGEIRVG CKYQAEIPDR LVEGESDNRN QQKMEMKVWD
       190        200        210        220        230        240
PDNPLTDRQI DQFLVVARAV GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR
       250        260        270        280        290        300
NGYDLAKAMS TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
       310        320        330        340        350        360
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV GSKPGMNGAG
       370        380        390        400        410        420
FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK YGGLKTPTQL EGATRGTTEP
       430        440        450        460        470        480
HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN RQTFLLQTTK LTRLARRMCR DLLQPRRAAR
       490        500        510        520        530        540
RPYAPINANA IKAECSIRLP KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT
       550        560        570        580        590        600
PINRNQLSQN RGLGGIMVKR AYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
       610        620        630        640        650        660
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLIAVRPPVP LPAPSHPAST

NEPIVLED

Isoforms

- Isoform 2 of Metastasis-associated protein MTA2

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O94776-1-unknown	MAANMY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94776-2-acetylation	AANMYR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O94776-2-acetylation	AANMYR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O94776-61-	SNAREF...	61			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O94776-174-unknown	MEMKVW...	174		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431346
O94776-174-unknown	MEMKVW...	174		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431797
O94776-183-unknown	NPLTDR...	183		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O94776-518-unknown	ATIVKD...	518		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13853
O94776-566-	AGAGVP...	566			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...VRLPLA	517	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13853
	...IVLED	668	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	517	LPLA.\|.ATIV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)