O94822: E3 ubiquitin-protein ligase listerin
Protein names | - E3 ubiquitin-protein ligase listerin - 2.3.2.27 - RING finger protein 160 - RING-type E3 ubiquitin transferase listerin {ECO:0000305} - Zinc finger protein 294 |
---|---|
Gene names | LTN1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O94822 |
6
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SQSDLGYVPA IQGAEEIDSL
70 80 90 100 110 120
VDSDFRMVLR KLSKKDVTTK LKAMQEFGTM CTERDTETVK GVLPYWPRIF CKISLDHDRR
130 140 150 160 170 180
VREATQQAFE KLILKVKKQL APYLKSLMGY WLMAQCDTYT PAAFAAKDAF EAAFPPSKQP
190 200 210 220 230 240
EAIAFCKDEI TSVLQDHLIK ETPDTLSDPQ TVPEEEREAK FYRVVTCSLL ALKRLLCLLP
250 260 270 280 290 300
DNELDSLEEK FKSLLSQNKF WKYGKHSVPQ IRSAYFELVS ALCQRIPQLM KEEASKVSPS
310 320 330 340 350 360
VLLSIDDSDP IVCPALWEAV LYTLTTIEDC WLHVNAKKSV FPKLSTVIRE GGRGLATVIY
370 380 390 400 410 420
PYLLPFISKL PQSITNPKLD FFKNFLTSLV AGLSTERTKT SSLESSAVIS AFFECLRFIM
430 440 450 460 470 480
QQNLGEEEIE QMLVNDQLIP FIDAVLKDPG LQHGQLFNHL AETLSSWEAK ADTEKDEKTA
490 500 510 520 530 540
HNLENVLIHF WERLSEICVA KISEPEADVE SVLGVSNLLQ VLQKPKSSLK SSKKKNGKVR
550 560 570 580 590 600
FADEILESNK ENEKCVSSEG EKIEGWELTT EPSLTHNSSG LLSPLRKKPL EDLVCKLADI
610 620 630 640 650 660
SINYVNERKS EQHLRFLSTL LDSFSSSRVF KMLLGDEKQS IVQAKPLEIA KLVQKNPAVQ
670 680 690 700 710 720
FLYQKLIGWL NEDQRKDFGF LVDILYSALR CCDNDMERKK VLDDLTKVDL KWNSLLKIIE
730 740 750 760 770 780
KACPSSDKHA LVTPWLKGDI LGEKLVNLAD CLCNEDLESR VSSESHFSER WTLLSLVLSQ
790 800 810 820 830 840
HVKNDYLIGD VYVERIIVRL HETLFKTKKL SEAESSDSSV SFICDVAYNY FSSAKGCLLM
850 860 870 880 890 900
PSSEDLLLTL FQLCAQSKEK THLPDFLICK LKNTWLSGVN LLVHQTDSSY KESTFLHLSA
910 920 930 940 950 960
LWLKNQVQAS SLDINSLQVL LSAVDDLLNT LLESEDSYLM GVYIGSVMPN DSEWEKMRQS
970 980 990 1000 1010 1020
LPMQWLHRPL LEGRLSLNYE CFKTDFKEQD IKTLPSHLCT SALLSKMVLI ALRKETVLEN
1030 1040 1050 1060 1070 1080
NELEKIIAEL LYSLQWCEEL DNPPIFLIGF CEILQKMNIT YDNLRVLGNT SGLLQLLFNR
1090 1100 1110 1120 1130 1140
SREHGTLWSL IIAKLILSRS ISSDEVKPHY KRKESFFPLT EGNLHTIQSL CPFLSKEEKK
1150 1160 1170 1180 1190 1200
EFSAQCIPAL LGWTKKDLCS TNGGFGHLAI FNSCLQTKSI DDGELLHGIL KIIISWKKEH
1210 1220 1230 1240 1250 1260
EDIFLFSCNL SEASPEVLGV NIEIIRFLSL FLKYCSSPLA ESEWDFIMCS MLAWLETTSE
1270 1280 1290 1300 1310 1320
NQALYSIPLV QLFACVSCDL ACDLSAFFDS TTLDTIGNLP VNLISEWKEF FSQGIHSLLL
1330 1340 1350 1360 1370 1380
PILVTVTGEN KDVSETSFQN AMLKPMCETL TYISKEQLLS HKLPARLVAD QKTNLPEYLQ
1390 1400 1410 1420 1430 1440
TLLNTLAPLL LFRARPVQIA VYHMLYKLMP ELPQYDQDNL KSYGDEEEEP ALSPPAALMS
1450 1460 1470 1480 1490 1500
LLSIQEDLLE NVLGCIPVGQ IVTIKPLSED FCYVLGYLLT WKLILTFFKA ASSQLRALYS
1510 1520 1530 1540 1550 1560
MYLRKTKSLN KLLYHLFRLM PENPTYAETA VEVPNKDPKT FFTEELQLSI RETTMLPYHI
1570 1580 1590 1600 1610 1620
PHLACSVYHM TLKDLPAMVR LWWNSSEKRV FNIVDRFTSK YVSSVLSFQE ISSVQTSTQL
1630 1640 1650 1660 1670 1680
FNGMTVKARA TTREVMATYT IEDIVIELII QLPSNYPLGS IIVESGKRVG VAVQQWRNWM
1690 1700 1710 1720 1730 1740
LQLSTYLTHQ NGSIMEGLAL WKNNVDKRFE GVEDCMICFS VIHGFNYSLP KKACRTCKKK
1750 1760
FHSACLYKWF TSSNKSTCPL CRETFF
Isoforms
- Isoform 2 of E3 ubiquitin-protein ligase listerin - Isoform 3 of E3 ubiquitin-protein ligase listerinSequence View
10 20 30 40 50 60
MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SQSDLGYVPA IQGAEEIDSL
70 80 90 100 110 120
VDSDFRMVLR KLSKKDVTTK LKAMQEFGTM CTERDTETVK GVLPYWPRIF CKISLDHDRR
130 140 150 160 170 180
VREATQQAFE KLILKVKKQL APYLKSLMGY WLMAQCDTYT PAAFAAKDAF EAAFPPSKQP
190 200 210 220 230 240
EAIAFCKDEI TSVLQDHLIK ETPDTLSDPQ TVPEEEREAK FYRVVTCSLL ALKRLLCLLP
250 260 270 280 290 300
DNELDSLEEK FKSLLSQNKF WKYGKHSVPQ IRSAYFELVS ALCQRIPQLM KEEASKVSPS
310 320 330 340 350 360
VLLSIDDSDP IVCPALWEAV LYTLTTIEDC WLHVNAKKSV FPKLSTVIRE GGRGLATVIY
370 380 390 400 410 420
PYLLPFISKL PQSITNPKLD FFKNFLTSLV AGLSTERTKT SSLESSAVIS AFFECLRFIM
430 440 450 460 470 480
QQNLGEEEIE QMLVNDQLIP FIDAVLKDPG LQHGQLFNHL AETLSSWEAK ADTEKDEKTA
490 500 510 520 530 540
HNLENVLIHF WERLSEICVA KISEPEADVE SVLGVSNLLQ VLQKPKSSLK SSKKKNGKVR
550 560 570 580 590 600
FADEILESNK ENEKCVSSEG EKIEGWELTT EPSLTHNSSG LLSPLRKKPL EDLVCKLADI
610 620 630 640 650 660
SINYVNERKS EQHLRFLSTL LDSFSSSRVF KMLLGDEKQS IVQAKPLEIA KLVQKNPAVQ
670 680 690 700 710 720
FLYQKLIGWL NEDQRKDFGF LVDILYSALR CCDNDMERKK VLDDLTKVDL KWNSLLKIIE
730 740 750 760 770 780
KACPSSDKHA LVTPWLKGDI LGEKLVNLAD CLCNEDLESR VSSESHFSER WTLLSLVLSQ
790 800 810 820 830 840
HVKNDYLIGD VYVERIIVRL HETLFKTKKL SEAESSDSSV SFICDVAYNY FSSAKGCLLM
850 860 870 880 890 900
PSSEDLLLTL FQLCAQSKEK THLPDFLICK LKNTWLSGVN LLVHQTDSSY KESTFLHLSA
910 920 930 940 950 960
LWLKNQVQAS SLDINSLQVL LSAVDDLLNT LLESEDSYLM GVYIGSVMPN DSEWEKMRQS
970 980 990 1000 1010 1020
LPMQWLHRPL LEGRLSLNYE CFKTDFKEQD IKTLPSHLCT SALLSKMVLI ALRKETVLEN
1030 1040 1050 1060 1070 1080
NELEKIIAEL LYSLQWCEEL DNPPIFLIGF CEILQKMNIT YDNLRVLGNT SGLLQLLFNR
1090 1100 1110 1120 1130 1140
SREHGTLWSL IIAKLILSRS ISSDEVKPHY KRKESFFPLT EGNLHTIQSL CPFLSKEEKK
1150 1160 1170 1180 1190 1200
EFSAQCIPAL LGWTKKDLCS TNGGFGHLAI FNSCLQTKSI DDGELLHGIL KIIISWKKEH
1210 1220 1230 1240 1250 1260
EDIFLFSCNL SEASPEVLGV NIEIIRFLSL FLKYCSSPLA ESEWDFIMCS MLAWLETTSE
1270 1280 1290 1300 1310 1320
NQALYSIPLV QLFACVSCDL ACDLSAFFDS TTLDTIGNLP VNLISEWKEF FSQGIHSLLL
1330 1340 1350 1360 1370 1380
PILVTVTGEN KDVSETSFQN AMLKPMCETL TYISKEQLLS HKLPARLVAD QKTNLPEYLQ
1390 1400 1410 1420 1430 1440
TLLNTLAPLL LFRARPVQIA VYHMLYKLMP ELPQYDQDNL KSYGDEEEEP ALSPPAALMS
1450 1460 1470 1480 1490 1500
LLSIQEDLLE NVLGCIPVGQ IVTIKPLSED FCYVLGYLLT WKLILTFFKA ASSQLRALYS
1510 1520 1530 1540 1550 1560
MYLRKTKSLN KLLYHLFRLM PENPTYAETA VEVPNKDPKT FFTEELQLSI RETTMLPYHI
1570 1580 1590 1600 1610 1620
PHLACSVYHM TLKDLPAMVR LWWNSSEKRV FNIVDRFTSK YVSSVLSFQE ISSVQTSTQL
1630 1640 1650 1660 1670 1680
FNGMTVKARA TTREVMATYT IEDIVIELII QLPSNYPLGS IIVESGKRVG VAVQQWRNWM
1690 1700 1710 1720 1730 1740
LQLSTYLTHQ NGSIMEGLAL WKNNVDKRFE GVEDCMICFS VIHGFNYSLP KKACRTCKKK
1750 1760
FHSACLYKWF TSSNKSTCPL CRETFF
10 20 30 40 50 60
MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SQSDLGYVPA IQGAEEIDSL
70 80 90 100 110 120
VDSDFRMVLR KLSKKDVTTK LKAMQEFGTM CTERDTETVK GVLPYWPRIF CKISLDHDRR
130 140 150 160 170 180
VREATQQAFE KLILKVKKQL APYLKSLMGY WLMAQCDTYT PAAFAAKDAF EAAFPPSKQP
190 200 210 220 230 240
EAIAFCKDEI TSVLQDHLIK ETPDTLSDPQ TVPEEEREAK FYRVVTCSLL ALKRLLCLLP
250 260 270 280 290 300
DNELDSLEEK FKSLLSQNKF WKYGKHSVPQ IRSAYFELVS ALCQRIPQLM KEEASKVSPS
310 320 330 340 350 360
VLLSIDDSDP IVCPALWEAV LYTLTTIEDC WLHVNAKKSV FPKLSTVIRE GGRGLATVIY
370 380 390 400 410 420
PYLLPFISKL PQSITNPKLD FFKNFLTSLV AGLSTERTKT SSLESSAVIS AFFECLRFIM
430 440 450 460 470 480
QQNLGEEEIE QMLVNDQLIP FIDAVLKDPG LQHGQLFNHL AETLSSWEAK ADTEKDEKTA
490 500 510 520 530 540
HNLENVLIHF WERLSEICVA KISEPEADVE SVLGVSNLLQ VLQKPKSSLK SSKKKNGKVR
550 560 570 580 590 600
FADEILESNK ENEKCVSSEG EKIEGWELTT EPSLTHNSSG LLSPLRKKPL EDLVCKLADI
610 620 630 640 650 660
SINYVNERKS EQHLRFLSTL LDSFSSSRVF KMLLGDEKQS IVQAKPLEIA KLVQKNPAVQ
670 680 690 700 710 720
FLYQKLIGWL NEDQRKDFGF LVDILYSALR CCDNDMERKK VLDDLTKVDL KWNSLLKIIE
730 740 750 760 770 780
KACPSSDKHA LVTPWLKGDI LGEKLVNLAD CLCNEDLESR VSSESHFSER WTLLSLVLSQ
790 800 810 820 830 840
HVKNDYLIGD VYVERIIVRL HETLFKTKKL SEAESSDSSV SFICDVAYNY FSSAKGCLLM
850 860 870 880 890 900
PSSEDLLLTL FQLCAQSKEK THLPDFLICK LKNTWLSGVN LLVHQTDSSY KESTFLHLSA
910 920 930 940 950 960
LWLKNQVQAS SLDINSLQVL LSAVDDLLNT LLESEDSYLM GVYIGSVMPN DSEWEKMRQS
970 980 990 1000 1010 1020
LPMQWLHRPL LEGRLSLNYE CFKTDFKEQD IKTLPSHLCT SALLSKMVLI ALRKETVLEN
1030 1040 1050 1060 1070 1080
NELEKIIAEL LYSLQWCEEL DNPPIFLIGF CEILQKMNIT YDNLRVLGNT SGLLQLLFNR
1090 1100 1110 1120 1130 1140
SREHGTLWSL IIAKLILSRS ISSDEVKPHY KRKESFFPLT EGNLHTIQSL CPFLSKEEKK
1150 1160 1170 1180 1190 1200
EFSAQCIPAL LGWTKKDLCS TNGGFGHLAI FNSCLQTKSI DDGELLHGIL KIIISWKKEH
1210 1220 1230 1240 1250 1260
EDIFLFSCNL SEASPEVLGV NIEIIRFLSL FLKYCSSPLA ESEWDFIMCS MLAWLETTSE
1270 1280 1290 1300 1310 1320
NQALYSIPLV QLFACVSCDL ACDLSAFFDS TTLDTIGNLP VNLISEWKEF FSQGIHSLLL
1330 1340 1350 1360 1370 1380
PILVTVTGEN KDVSETSFQN AMLKPMCETL TYISKEQLLS HKLPARLVAD QKTNLPEYLQ
1390 1400 1410 1420 1430 1440
TLLNTLAPLL LFRARPVQIA VYHMLYKLMP ELPQYDQDNL KSYGDEEEEP ALSPPAALMS
1450 1460 1470 1480 1490 1500
LLSIQEDLLE NVLGCIPVGQ IVTIKPLSED FCYVLGYLLT WKLILTFFKA ASSQLRALYS
1510 1520 1530 1540 1550 1560
MYLRKTKSLN KLLYHLFRLM PENPTYAETA VEVPNKDPKT FFTEELQLSI RETTMLPYHI
1570 1580 1590 1600 1610 1620
PHLACSVYHM TLKDLPAMVR LWWNSSEKRV FNIVDRFTSK YVSSVLSFQE ISSVQTSTQL
1630 1640 1650 1660 1670 1680
FNGMTVKARA TTREVMATYT IEDIVIELII QLPSNYPLGS IIVESGKRVG VAVQQWRNWM
1690 1700 1710 1720 1730 1740
LQLSTYLTHQ NGSIMEGLAL WKNNVDKRFE GVEDCMICFS VIHGFNYSLP KKACRTCKKK
1750 1760
FHSACLYKWF TSSNKSTCPL CRETFF
Protein Neighborhood
Domains & Features
6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O94822-1-unknown | MGGKNK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O94822-1-unknown | MGGKNK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt80069 | |||
O94822-1-unknown | MGGKNK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt100784 | |||
O94822-46-unknown | GYVPAI... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177148 | |||
O94822-46-unknown | GYVPAI... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177147 | |||
O94822-46- | GYVPAI... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O94822-47- | YVPAIQ... | 47 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O94822-47-unknown | YVPAIQ... | 47 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178451 | |||
O94822-47-unknown | YVPAIQ... | 47 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178450 | |||
O94822-751-unknown | CLCNED... | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10988 | |||
O94822-751-unknown | CLCNED... | 751 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156476 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LVNDQL | 437 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75687 | |||
...LVNDQL | 437 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92768 | |||
...VNLADC | 750 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10988 | |||
...VNLADC | 750 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139958 | |||
...RETFF | 1766 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...RETFF | 1766 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75688 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 750 | LADC.|.CLCN | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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