O95831: Apoptosis-inducing factor 1, mitochondrial
Protein names | - Apoptosis-inducing factor 1, mitochondrial - 1.1.1.- - Programmed cell death protein 8 |
---|---|
Gene names | AIFM1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O95831 |
14
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
Isoforms
- Isoform 2 of Apoptosis-inducing factor 1, mitochondrial - Isoform 3 of Apoptosis-inducing factor 1, mitochondrial - Isoform 4 of Apoptosis-inducing factor 1, mitochondrial - Isoform 5 of Apoptosis-inducing factor 1, mitochondrial - Isoform 6 of Apoptosis-inducing factor 1, mitochondrialSequence View
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
10 20 30 40 50 60
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS
70 80 90 100 110 120
GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG
130 140 150 160 170 180
EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW
190 200 210 220 230 240
FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD
250 260 270 280 290 300
NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
310 320 330 340 350 360
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG
370 380 390 400 410 420
VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG
430 440 450 460 470 480
FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS
490 500 510 520 530 540
MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE
550 560 570 580 590 600
ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
610
LNEVAKLFNI HED
Protein Neighborhood
Domains & Features
14 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O95831-1-unknown | MFRCGG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66563 | |||
O95831-1-unknown | MFRCGG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66564 | |||
O95831-1-unknown | MFRCGG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66565 | |||
O95831-55-unknown | ASSGAS... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167670 | |||
O95831-55- | ASSGAS... | 55 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O95831-72-unknown | IVGLST... | 72 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O95831-72-unknown | IVGLST... | 72 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159407 | |||
O95831-72- | IVGLST... | 72 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O95831-75-unknown | LSTVGA... | 75 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O95831-75-unknown | LSTVGA... | 75 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159409 | |||
O95831-75- | LSTVGA... | 75 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O95831-88-unknown | MKEDEK... | 88 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66567 | |||
O95831-88-unknown | MKEDEK... | 88 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96153 | |||
O95831-88-unknown | MKEDEK... | 88 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96152 | |||
O95831-102-unknown | LGLTPE... | 102 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O95831-102-unknown | LGLTPE... | 102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115862 | |||
O95831-102-unknown | LGLTPE... | 102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115864 | |||
O95831-102-unknown | LGLTPE... | 102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115863 | |||
O95831-112-unknown | KAALSA... | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165082 | |||
O95831-112-unknown | KAALSA... | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165084 | |||
O95831-112-unknown | KAALSA... | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165083 | |||
O95831-112- | KAALSA... | 112 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O95831-114-unknown | ALSASE... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164585 | |||
O95831-114-unknown | ALSASE... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164587 | |||
O95831-114-unknown | ALSASE... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164586 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O95831-114- | ALSASE... | 114 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
O95831-353-unknown | MEKVRR... | 353 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66566 | |||
O95831-353-unknown | MEKVRR... | 353 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96093 | |||
O95831-353-unknown | MEKVRR... | 353 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96092 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...NIHED | 613 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...NIHED | 613 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62184 | |||
...NIHED | 613 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62181 | |||
...NIHED | 613 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62182 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|