O96017: Serine/threonine-protein kinase Chk2

General Information

Protein names	- Serine/threonine-protein kinase Chk2 - 2.7.11.1 - CHK2 checkpoint homolog - Cds1 homolog - Hucds1 - hCds1 - Checkpoint kinase 2
Gene names	CHEK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O96017

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase Chk2 - Isoform 3 of Serine/threonine-protein kinase Chk2 - Isoform 4 of Serine/threonine-protein kinase Chk2 - Isoform 5 of Serine/threonine-protein kinase Chk2 - Isoform 6 of Serine/threonine-protein kinase Chk2 - Isoform 7 of Serine/threonine-protein kinase Chk2 - Isoform 8 of Serine/threonine-protein kinase Chk2 - Isoform 9 of Serine/threonine-protein kinase Chk2 - Isoform 10 of Serine/threonine-protein kinase Chk2 - Isoform 11 of Serine/threonine-protein kinase Chk2 - Isoform 12 of Serine/threonine-protein kinase Chk2 - Isoform 13 of Serine/threonine-protein kinase Chk2

Sequence View

        10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL         10         20         30         40         50         60
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
        70         80         90        100        110        120
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
       130        140        150        160        170        180
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
       190        200        210        220        230        240
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
       250        260        270        280        290        300
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
       310        320        330        340        350        360
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
       370        380        390        400        410        420
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
       430        440        450        460        470        480
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
       490        500        510        520        530        540
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA

AVL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O96017-1-unknown	MSRESD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70561
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70562
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70563
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70564
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70565
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70566
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70567
O96017-1-unknown	MSRESD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70568
O96017-73-	SIPEDQ...	73		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O96017-73-	SIPEDQ...	73		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174268
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174269
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174270
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174271
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174272
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174273
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174274
O96017-73-unknown	SIPEDQ...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174275

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CAAVL	543	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CAAVL	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66180
...CAAVL	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66181
...CAAVL	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66186

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)