P02775: Platelet basic protein

General Information

Protein names	- Platelet basic protein - PBP - C-X-C motif chemokine 7 - Leukocyte-derived growth factor - LDGF - Macrophage-derived growth factor - MDGF - Small-inducible cytokine B7 - Connective tissue-activating peptide III - CTAP-III - LA-PF4 - Low-affinity platelet factor IV - TC-2 - Connective tissue-activating peptide III(1-81) - CTAP-III(1-81) - Beta-thromboglobulin - Beta-TG - Neutrophil-activating peptide 2(74) - NAP-2(74) - Neutrophil-activating peptide 2(73) - NAP-2(73) - Neutrophil-activating peptide 2 - NAP-2 - TC-1 - Neutrophil-activating peptide 2(1-66) - NAP-2(1-66) - Neutrophil-activating peptide 2(1-63) - NAP-2(1-63)
Gene names	PPBP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02775

14 N-termini

13 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE ESLDSDLYAE
        70         80         90        100        110        120
LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD GRKICLDPDA PRIKKIVQKK

LAGDESAD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 13 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P02775-35-unknown	SSTKGQ...	35	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-44-unknown	NLAKGK...	44	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-44-unknown	NLAKGK...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16279
P02775-48-unknown	GKEESL...	48	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-48-unknown	GKEESL...	48		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02775-55-unknown	SDLYAE...	55	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-56-unknown	DLYAEL...	56	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-57-unknown	LYAELR...	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25564
P02775-59-unknown	AELRCM...	59	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02775-59-unknown	AELRCM...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8410
P02775-61-unknown	LRCMCI...	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25565
P02775-63-unknown	CMCIKT...	63		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02775-64-unknown	MCIKTT...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25566
P02775-77-unknown	IQSLEV...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25567
P02775-82-unknown	VIGKGT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25568
P02775-98-unknown	LKDGRK...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25569
P02775-116-unknown	IVQKKL...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25570

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GQTKRN	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16279
...SLDSDL	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25564
...DSDLYA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8410
...DLYAEL	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25565
...AELRCM	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25566
...IHPKNI	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25567
...IQSLEV	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25568
...EVIATL	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25569
...PRIKKI	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25570
...VQKKLA	121	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLAGDE	124	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AGDESA	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DESAD	128	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	43	TKRN.\|.NLAK	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
MMP9_HUMAN	56	DSDL.\|.LYAE	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
CMA1_HUMAN	58	DLYA.\|.AELR	inferred from experiment	unknown	MEROPS	Brandt E	Schiemann F et al.:Mast cells and neutrophils prot... (S01.140)	16317101,
MMP9_HUMAN	60	YAEL.\|.LRCM	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	63	LRCM.\|.MCIK	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	76	PKNI.\|.IQSL	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	81	SLEV.\|.VIGK	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	97	IATL.\|.LKDG	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,
MMP9_HUMAN	115	IKKI.\|.IVQK	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.002)	14550288,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)