P04637: Cellular tumor antigen p53

General Information

Protein names	- Cellular tumor antigen p53 - Antigen NY-CO-13 - Phosphoprotein p53 - Tumor suppressor p53
Gene names	TP53
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04637

10 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cellular tumor antigen p53 - Isoform 3 of Cellular tumor antigen p53 - Isoform 4 of Cellular tumor antigen p53 - Isoform 5 of Cellular tumor antigen p53 - Isoform 6 of Cellular tumor antigen p53 - Isoform 7 of Cellular tumor antigen p53 - Isoform 8 of Cellular tumor antigen p53 - Isoform 9 of Cellular tumor antigen p53

Sequence View

        10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD         10         20         30         40         50         60
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
        70         80         90        100        110        120
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
       130        140        150        160        170        180
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
       190        200        210        220        230        240
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
       250        260        270        280        290        300
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
       310        320        330        340        350        360
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
       370        380        390
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04637-1-unknown	MEEPQS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04637-1-unknown	MEEPQS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84063
P04637-1-unknown	MEEPQS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84064
P04637-22-unknown	LWKLLP...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1540
P04637-22-unknown	LWKLLP...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136951
P04637-22-unknown	LWKLLP...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136952
P04637-25-unknown	LLPENN...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13665
P04637-25-unknown	LLPENN...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137184
P04637-25-unknown	LLPENN...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137187
P04637-40-unknown	MDDLML...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84065
P04637-40-unknown	MDDLML...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84066
P04637-40-unknown	MDDLML...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84067
P04637-40-unknown	MDDLML...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101406
P04637-40-unknown	MDDLML...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101407
P04637-96-unknown	SVPSQK...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178385
P04637-96-unknown	SVPSQK...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178386
P04637-96-unknown	SVPSQK...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178387
P04637-96-unknown	SVPSQK...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178388
P04637-96-unknown	SVPSQK...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178389
P04637-96-	SVPSQK...	96		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84068
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84069
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84070
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101592
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101593
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101594
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101595
P04637-133-unknown	MFCQLA...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101596
P04637-187-	GLAPPQ...	187		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04637-187-unknown	GLAPPQ...	187	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1543
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139492
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139493
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139494
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144619
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144621
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144622
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146122
P04637-187-unknown	GLAPPQ...	187	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146123
P04637-306-unknown	RALPNN...	306	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13668
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145665
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145666
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145667
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149044
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149045
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149046
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150028
P04637-306-unknown	RALPNN...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150029

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ETFSDL	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1540
...ETFSDL	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119774
...ETFSDL	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119776
...SDLWKL	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13665
...SDLWKL	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120099
...SDLWKL	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120102
...CSDSDG	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1543
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122582
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122583
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122584
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127886
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127888
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127889
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129423
...CSDSDG	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129424
...PGSTKR	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13668
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128963
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128964
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128965
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132428
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132429
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132430
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133420
...PGSTKR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133421
...GPDSD	393	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPDSD	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79686
...GPDSD	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79683

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	21	FSDL.\|.LWKL	inferred from experiment	unknown	MEROPS	Cohen GM	Sayan BS et al.:p53 is cleaved by caspases gene... (C14.003)	16531411,
GRAK_HUMAN	24	LWKL.\|.LLPE	inferred from experiment	unknown	MEROPS	Fan Z	Hua G et al.:Ignition of p53 bomb sensitizes... (S01.146)	19201868,
CASP3_HUMAN	186	DSDG.\|.GLAP	inferred from experiment	unknown	MEROPS	Cohen GM	Sayan BS et al.:p53 is cleaved by caspases gene... (C14.003)	16531411,
GRAK_HUMAN	305	STKR.\|.RALP	inferred from experiment	unknown	MEROPS	Fan Z	Hua G et al.:Ignition of p53 bomb sensitizes... (S01.146)	19201868,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)