P04908: Histone H2A type 1-B/E

General Information

Protein names	- Histone H2A type 1-B/E - Histone H2A.2 - Histone H2A/a - Histone H2A/m
Gene names	HIST1H2AE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04908

9 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT
        70         80         90        100        110        120
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK
       130
TESHHKAKGK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04908-2-unknown	MSGRGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04908-2-Acetylation	SGRGKQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04908-22-unknown	AGLQFP...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9931
P04908-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13914
P04908-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9932
P04908-61-unknown	AEILEL...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9933
P04908-83-unknown	HLQLAI...	83		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9934
P04908-85-	QLAIRN...	85			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P04908-106-	GGVLPN...	106			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04908-107-	GVLPNI...	107			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TRSSRA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9931
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13914
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9932
...LEYLTA	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9933
...RIIPRH	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9934
...KAKGK	130	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	21	SSRA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	60	YLTA.\|.AEIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	82	IPRH.\|.HLQL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)