P06132: Uroporphyrinogen decarboxylase

General Information

Protein names	- Uroporphyrinogen decarboxylase - UPD - URO-D - 4.1.1.37
Gene names	UROD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06132

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEANGLGPQG FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR AAQDFFSTCR
        70         80         90        100        110        120
SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM VPGKGPSFPE PLREEQDLER
       130        140        150        160        170        180
LRDPEVVASE LGYVFQAITL TRQRLAGRVP LIGFAGAPWT LMTYMVEGGG SSTMAQAKRW
       190        200        210        220        230        240
LYQRPQASHQ LLRILTDALV PYLVGQVVAG AQALQLFESH AGHLGPQLFN KFALPYIRDV
       250        260        270        280        290        300
AKQVKARLRE AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARECVGKTVT
       310        320        330        340        350        360
LQGNLDPCAL YASEEEIGQL VKQMLDDFGP HRYIANLGHG LYPDMDPEHV GAFVDAVHKH

SRLLRQN

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06132-1-Acetylation	MEANGL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06132-1-Acetylation	MEANGL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P06132-1-Acetylation	MEANGL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P06132-1-Acetylation	MEANGL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P06132-1-Acetylation	MEANGL...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06132-5-	GLGPQG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06132-5-	GLGPQG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06132-5-	GLGPQG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06132-5-	GLGPQG...	5			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06132-61-	SPEACC...	61			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06132-100-	MVPGKG...	100			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GAQALQ	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404489
...WTVAPK	288	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400253
...LLRQN	367	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)