TopFIND 4.0

P07602: Prosaposin

General Information

Protein names
- Prosaposin
- Proactivator polypeptide
- Saposin-A
- Protein A
- Saposin-B-Val
- Saposin-B
- Cerebroside sulfate activator
- CSAct
- Dispersin
- Sphingolipid activator protein 1
- SAP-1
- Sulfatide/GM1 activator
- Saposin-C
- A1 activator
- Co-beta-glucosidase
- Glucosylceramidase activator
- Sphingolipid activator protein 2
- SAP-2
- Saposin-D
- Component C
- Protein C
Gene names PSAP
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P07602

12

N-termini

6

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS 
        70         80         90        100        110        120 
LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI 
       130        140        150        160        170        180 
IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY 
       190        200        210        220        230        240 
PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI 
       250        260        270        280        290        300 
CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE 
       310        320        330        340        350        360 
PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV 
       370        380        390        400        410        420 
VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD 
       430        440        450        460        470        480 
RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG 
       490        500        510        520    
ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN

Isoforms

- Isoform Sap-mu-6 of Prosaposin - Isoform Sap-mu-9 of Prosaposin

Sequence View

        10         20         30         40         50         60 
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS 
        70         80         90        100        110        120 
LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI 
       130        140        150        160        170        180 
IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY 
       190        200        210        220        230        240 
PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI 
       250        260        270        280        290        300 
CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE 
       310        320        330        340        350        360 
PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV 
       370        380        390        400        410        420 
VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD 
       430        440        450        460        470        480 
RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG 
       490        500        510        520    
ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN         10         20         30         40         50         60 
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS 
        70         80         90        100        110        120 
LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI 
       130        140        150        160        170        180 
IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY 
       190        200        210        220        230        240 
PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI 
       250        260        270        280        290        300 
CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE 
       310        320        330        340        350        360 
PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV 
       370        380        390        400        410        420 
VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD 
       430        440        450        460        470        480 
RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG 
       490        500        510        520    
ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)