P07686: Beta-hexosaminidase subunit beta

General Information

Protein names	- Beta-hexosaminidase subunit beta - 3.2.1.52 - Beta-N-acetylhexosaminidase subunit beta - Hexosaminidase subunit B - Cervical cancer proto-oncogene 7 protein - HCC-7 - N-acetyl-beta-glucosaminidase subunit beta - Beta-hexosaminidase subunit beta chain B - Beta-hexosaminidase subunit beta chain A
Gene names	HEXB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07686

9 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELCGLGLPR PPMLLALLLA TLLAAMLALL TQVALVVQVA EAARAPSVSA KPGPALWPLP
        70         80         90        100        110        120
LSVKMTPNLL HLAPENFYIS HSPNSTAGPS CTLLEEAFRR YHGYIFGFYK WHHEPAEFQA
       130        140        150        160        170        180
KTQVQQLLVS ITLQSECDAF PNISSDESYT LLVKEPVAVL KANRVWGALR GLETFSQLVY
       190        200        210        220        230        240
QDSYGTFTIN ESTIIDSPRF SHRGILIDTS RHYLPVKIIL KTLDAMAFNK FNVLHWHIVD
       250        260        270        280        290        300
DQSFPYQSIT FPELSNKGSY SLSHVYTPND VRMVIEYARL RGIRVLPEFD TPGHTLSWGK
       310        320        330        340        350        360
GQKDLLTPCY SRQNKLDSFG PINPTLNTTY SFLTTFFKEI SEVFPDQFIH LGGDEVEFKC
       370        380        390        400        410        420
WESNPKIQDF MRQKGFGTDF KKLESFYIQK VLDIIATINK GSIVWQEVFD DKAKLAPGTI
       430        440        450        460        470        480
VEVWKDSAYP EELSRVTASG FPVILSAPWY LDLISYGQDW RKYYKVEPLD FGGTQKQKQL
       490        500        510        520        530        540
FIGGEACLWG EYVDATNLTP RLWPRASAVG ERLWSSKDVR DMDDAYDRLT RHRCRMVERG
       550
IAAQPLYAGY CNHENM

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07686-43-unknown	ARAPSV...	43	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07686-47-	SVSAKP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07686-48-	VSAKPG...	48		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07686-48-	VSAKPG...	48		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07686-48-	VSAKPG...	48		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P07686-48-	VSAKPG...	48		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P07686-49-	SAKPGP...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07686-49-	SAKPGP...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07686-49-	SAKPGP...	49		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P07686-49-	SAKPGP...	49		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P07686-49-	SAKPGP...	49		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P07686-50-	AKPGPA...	50		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07686-50-	AKPGPA...	50		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07686-122-unknown	TQVQQL...	122	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07686-226-unknown	MAFNKF...	226	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426285
P07686-315-unknown	KLDSFG...	315	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07686-522-unknown	MDDAYD...	522	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424939

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TPCYSR	311	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...NHENM	556	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)