P08047: Transcription factor Sp1

General Information

Protein names	- Transcription factor Sp1
Gene names	SP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08047

8 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transcription factor Sp1 - Isoform 3 of Transcription factor Sp1

Sequence View

        10         20         30         40         50         60
MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP
        70         80         90        100        110        120
LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS
       130        140        150        160        170        180
KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ
       190        200        210        220        230        240
TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG
       250        260        270        280        290        300
LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT
       310        320        330        340        350        360
SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS
       370        380        390        400        410        420
GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL
       430        440        450        460        470        480
SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ
       490        500        510        520        530        540
TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS
       550        560        570        580        590        600
GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR
       610        620        630        640        650        660
REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW
       670        680        690        700        710        720
SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS
       730        740        750        760        770        780
VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI

SGNGF         10         20         30         40         50         60
MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP
        70         80         90        100        110        120
LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS
       130        140        150        160        170        180
KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ
       190        200        210        220        230        240
TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG
       250        260        270        280        290        300
LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT
       310        320        330        340        350        360
SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS
       370        380        390        400        410        420
GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL
       430        440        450        460        470        480
SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ
       490        500        510        520        530        540
TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS
       550        560        570        580        590        600
GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR
       610        620        630        640        650        660
REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW
       670        680        690        700        710        720
SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS
       730        740        750        760        770        780
VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI

SGNGF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08047-2-unknown	MSDQDH...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08047-1-unknown	MSDQDH...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90314
P08047-2-Acetylation	SDQDHS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08047-2-Acetylation	SDQDHS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111238
P08047-8-unknown	MDEMTA...	8		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90313
P08047-8-unknown	MDEMTA...	8		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404263
P08047-8-unknown	MDEMTA...	8		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458133
P08047-8-unknown	MDEMTA...	8		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107159
P08047-62-unknown	ALLAAT...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13936
P08047-62-unknown	ALLAAT...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139532
P08047-200-unknown	GSGQIQ...	200			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P08047-200-unknown	GSGQIQ...	200		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162141
P08047-200-unknown	GSGQIQ...	200		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162142
P08047-200-	GSGQIQ...	200			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P08047-200-	GSGQIQ...	200			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P08047-200-	GSGQIQ...	200			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08047-200-	GSGQIQ...	200			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08047-591-unknown	AQPQAG...	591		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1603
P08047-591-unknown	AQPQAG...	591		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153909
P08047-591-unknown	AQPQAG...	591		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154380

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QPSPLA	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13936
...QPSPLA	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122622
...IIPGAN	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457804
...IIPGAN	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111001
...IIPGAN	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111000
...QQAVPL	237	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458133
...QQAVPL	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111004
...QQAVPL	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111003
...ENSPDA	590	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1603
...ENSPDA	590	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137331
...ENSPDA	590	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137801
...SGNGF	785	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SGNGF	785	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85932
...SGNGF	785	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85931

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	61	SPLA.\|.ALLA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	590	SPDA.\|.AQPQ	inferred from experiment	unknown	MEROPS	Bommert K	Rickers A et al.:Cleavage of transcription facto... (C14.003)	10103059,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)