P09493: Tropomyosin alpha-1 chain

General Information

Protein names	- Tropomyosin alpha-1 chain - Alpha-tropomyosin - Tropomyosin-1
Gene names	TPM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09493

10 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tropomyosin alpha-1 chain - Isoform 3 of Tropomyosin alpha-1 chain - Isoform 4 of Tropomyosin alpha-1 chain - Isoform 5 of Tropomyosin alpha-1 chain - Isoform 6 of Tropomyosin alpha-1 chain - Isoform 7 of Tropomyosin alpha-1 chain - Isoform 8 of Tropomyosin alpha-1 chain - Isoform 9 of Tropomyosin alpha-1 chain - Isoform 10 of Tropomyosin alpha-1 chain

Sequence View

        10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI         10         20         30         40         50         60
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY
        70         80         90        100        110        120
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
       130        140        150        160        170        180
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE
       190        200        210        220        230        240
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE
       250        260        270        280
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92857
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92858
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92860
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92861
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92862
P09493-1-unknown	MDAIKK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92863
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96871
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96872
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96873
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96874
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96875
P09493-1-Acetylation	MDAIKK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96876
P09493-2-acetylation	DAIKKK...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181521
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181522
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181523
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181524
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181525
P09493-2-acetylation	DAIKKK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181526
P09493-16-	ENALDR...	16			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09493-16-acetylation	ENALDR...	16	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181513
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181514
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181515
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181516
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181517
P09493-16-acetylation	ENALDR...	16	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181518
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181505
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181506
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181507
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181508
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181509
P09493-16-unknown	ENALDR...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181510
P09493-23-unknown	EQAEAD...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181500
P09493-23-unknown	EQAEAD...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181501
P09493-23-unknown	EQAEAD...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181502
P09493-23-Pyrrolidone carboxylic acid (Glu)	EQAEAD...	23	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09493-23-Pyrrolidone carboxylic acid (Glu)	EQAEAD...	23	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181495
P09493-23-Pyrrolidone carboxylic acid (Glu)	EQAEAD...	23	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181496
P09493-23-Pyrrolidone carboxylic acid (Glu)	EQAEAD...	23	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181497
P09493-23-	EQAEAD...	23			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09493-176-unknown	LERAEE...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11139
P09493-176-unknown	LERAEE...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144306
P09493-176-unknown	LERAEE...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145744
P09493-176-unknown	LERAEE...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145746
P09493-176-unknown	LERAEE...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145747

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IIESDL	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11139
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126716
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127566
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129041
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129042
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129043
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129044
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129045
...IIESDL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129047
...DMTSI	284	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DMTSI	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88476
...DMTSI	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88478

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	175	ESDL.\|.LERA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)