P09496: Clathrin light chain A

General Information

Protein names	- Clathrin light chain A - Lca
Gene names	CLTA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09496

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Non-brain of Clathrin light chain A - Isoform 3 of Clathrin light chain A - Isoform 4 of Clathrin light chain A - Isoform 5 of Clathrin light chain A

Sequence View

        10         20         30         40         50         60
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP
        70         80         90        100        110        120
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER
       130        140        150        160        170        180
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV
       190        200        210        220        230        240
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS

LKQAPLVH         10         20         30         40         50         60
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP
        70         80         90        100        110        120
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER
       130        140        150        160        170        180
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV
       190        200        210        220        230        240
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS

LKQAPLVH         10         20         30         40         50         60
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP
        70         80         90        100        110        120
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER
       130        140        150        160        170        180
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV
       190        200        210        220        230        240
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS

LKQAPLVH         10         20         30         40         50         60
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP
        70         80         90        100        110        120
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER
       130        140        150        160        170        180
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV
       190        200        210        220        230        240
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS

LKQAPLVH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09496-1-unknown	MAELDP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09496-1-unknown	MAELDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70904
P09496-1-unknown	MAELDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70905
P09496-1-unknown	MAELDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70906
P09496-1-unknown	MAELDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70907
P09496-77-unknown	GVMNGE...	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1616
P09496-77-unknown	GVMNGE...	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1131
P09496-77-unknown	GVMNGE...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141107
P09496-77-unknown	GVMNGE...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141108
P09496-77-unknown	GVMNGE...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141109
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P09496-77-	GVMNGE...	77		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P09496-93-unknown	SYAAIS...	93		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P09496-93-unknown	SYAAIS...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161389
P09496-93-unknown	SYAAIS...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161390
P09496-93-unknown	SYAAIS...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161391
P09496-93-	SYAAIS...	93		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P09496-93-	SYAAIS...	93		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P09496-93-	SYAAIS...	93		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09496-93-	SYAAIS...	93		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P09496-95-	AAISQV...	95		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09496-95-unknown	AAISQV...	95	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166658
P09496-95-unknown	AAISQV...	95	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166659
P09496-95-unknown	AAISQV...	95	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166660
P09496-190-	LEQAAE...	190		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P09496-190-unknown	LEQAAE...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176662

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PDAVDG	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1616
...PDAVDG	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1131
...PDAVDG	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124261
...PDAVDG	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124262
...PDAVDG	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124263
...APLVH	248		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...APLVH	248	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...APLVH	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66525
...APLVH	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66522
...APLVH	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66524
...APLVH	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66523
...APLVH	248		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	76	AVDG.\|.GVMN	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> CLCA_HUMAN @76
CASP1_HUMAN	76	AVDG.\|.GVMN	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)