P09622: Dihydrolipoyl dehydrogenase, mitochondrial

General Information

Protein names	- Dihydrolipoyl dehydrogenase, mitochondrial - 1.8.1.4 {ECO:0000269\|PubMed:15712224, ECO:0000269\|PubMed:16442803, ECO:0000269\|PubMed:16770810, ECO:0000269\|PubMed:17404228, ECO:0000269\|PubMed:20160912, ECO:0000269\|PubMed:20385101} - Dihydrolipoamide dehydrogenase - Glycine cleavage system L protein
Gene names	DLD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09622

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Dihydrolipoyl dehydrogenase, mitochondrial - Isoform 3 of Dihydrolipoyl dehydrogenase, mitochondrial

Sequence View

        10         20         30         40         50         60
MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA
        70         80         90        100        110        120
AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL
       130        140        150        160        170        180
DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL
       190        200        210        220        230        240
IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT
       250        260        270        280        290        300
AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK
       310        320        330        340        350        360
AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP
       370        380        390        400        410        420
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK
       430        440        450        460        470        480
FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI
       490        500
ARVCHAHPTL SEAFREANLA ASFGKSINF         10         20         30         40         50         60
MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA
        70         80         90        100        110        120
AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL
       130        140        150        160        170        180
DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL
       190        200        210        220        230        240
IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT
       250        260        270        280        290        300
AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK
       310        320        330        340        350        360
AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP
       370        380        390        400        410        420
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK
       430        440        450        460        470        480
FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI
       490        500
ARVCHAHPTL SEAFREANLA ASFGKSINF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P09622-36-	ADQPID...	36		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P09622-36-unknown	ADQPID...	36	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09622-100-unknown	MAHGKD...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442399
P09622-405-	SEEQLK...	405		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KSINF	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KSINF	509	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KSINF	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)