P10644: cAMP-dependent protein kinase type I-alpha regulatory subunit

General Information

Protein names	- cAMP-dependent protein kinase type I-alpha regulatory subunit - Tissue-specific extinguisher 1 - TSE1
Gene names	PRKAR1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10644

10 N-termini

9 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE
        70         80         90        100        110        120
EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK
       130        140        150        160        170        180
DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG
       190        200        210        220        230        240
ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL
       250        260        270        280        290        300
RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA
       310        320        330        340        350        360
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG
       370        380
PCSDILKRNI QQYNSFVSLS V

Isoforms

- Isoform 2 of cAMP-dependent protein kinase type I-alpha regulatory subunit

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 9 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10644-1-unknown	MESGST...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78560
P10644-1-Acetylation	MESGST...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10644-1-Acetylation	MESGST...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P10644-1-Acetylation	MESGST...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P10644-1-Acetylation	MESGST...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P10644-1-Acetylation	MESGST...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P10644-1-Acetylation	MESGST...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103301
P10644-2-Acetylation	MESGST...	1	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10644-2-unknown	ESGSTA...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10644-2-unknown	ESGSTA...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110954
P10644-2-unknown	ESGSTA...	2		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10644-98-unknown	GAISAE...	98		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171508
P10644-98-	GAISAE...	98			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10644-135-	NVLFSH...	135			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10644-135-unknown	NVLFSH...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177985
P10644-270-	ALEPVQ...	270			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P10644-270-	ALEPVQ...	270			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10644-270-unknown	ALEPVQ...	270		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175954

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARPERP	45	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467500
...ARPERP	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112877
...EAKQIQ	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467867
...EAKQIQ	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112883
...DAASYV	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466649
...DAASYV	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112881
...MFSVSF	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464715
...MFSVSF	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112873
...TVIQQG	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464701
...TVIQQG	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112875
...DQGETD	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465013
...DQGETD	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112885
...FGELAL	204	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465445
...FGELAL	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112871
...FIILEG	297	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467311
...FIILEG	297	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112879
...VSLSV	381	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)