P11362: Fibroblast growth factor receptor 1

General Information

Protein names	- Fibroblast growth factor receptor 1 - FGFR-1 - 2.7.10.1 {ECO:0000269\|PubMed:1379697, ECO:0000269\|PubMed:15117958, ECO:0000269\|PubMed:18480409, ECO:0000269\|PubMed:19224897, ECO:0000269\|PubMed:19665973, ECO:0000269\|PubMed:20133753, ECO:0000269\|PubMed:8622701} - Basic fibroblast growth factor receptor 1 - BFGFR - bFGF-R-1 - Fms-like tyrosine kinase 2 - FLT-2 - N-sam - Proto-oncogene c-Fgr - CD331
Gene names	FGFR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11362

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Fibroblast growth factor receptor 1 - Isoform 3 of Fibroblast growth factor receptor 1 - Isoform 4 of Fibroblast growth factor receptor 1 - Isoform 5 of Fibroblast growth factor receptor 1 - Isoform 6 of Fibroblast growth factor receptor 1 - Isoform 7 of Fibroblast growth factor receptor 1 - Isoform 8 of Fibroblast growth factor receptor 1 - Isoform 9 of Fibroblast growth factor receptor 1 - Isoform 10 of Fibroblast growth factor receptor 1 - Isoform 11 of Fibroblast growth factor receptor 1 - Isoform 12 of Fibroblast growth factor receptor 1 - Isoform 13 of Fibroblast growth factor receptor 1 - Isoform 14 of Fibroblast growth factor receptor 1 - Isoform 15 of Fibroblast growth factor receptor 1 - Isoform 16 of Fibroblast growth factor receptor 1 - Isoform 17 of Fibroblast growth factor receptor 1 - Isoform 18 of Fibroblast growth factor receptor 1 - Isoform 19 of Fibroblast growth factor receptor 1 - Isoform 20 of Fibroblast growth factor receptor 1 - Isoform 21 of Fibroblast growth factor receptor 1

Sequence View

        10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR         10         20         30         40         50         60
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
        70         80         90        100        110        120
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
       130        140        150        160        170        180
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
       190        200        210        220        230        240
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
       250        260        270        280        290        300
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
       310        320        330        340        350        360
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
       370        380        390        400        410        420
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
       430        440        450        460        470        480
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
       490        500        510        520        530        540
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
       550        560        570        580        590        600
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
       610        620        630        640        650        660
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
       670        680        690        700        710        720
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
       730        740        750        760        770        780
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
       790        800        810        820
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75101
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75103
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75104
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75105
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75107
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75113
P11362-1-unknown	MWSWKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101156
P11362-22-unknown	RPSPTL...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P11362-22-unknown	RPSPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113067
P11362-22-unknown	RPSPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113068
P11362-22-unknown	RPSPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113069
P11362-22-unknown	RPSPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113070
P11362-22-unknown	RPSPTL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113073
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75109
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75111
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101622
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101623
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101635
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101621
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101624
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101625
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101626
P11362-161-unknown	MEKKLH...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101634
P11362-369-unknown	MTSPLY...	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22681
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146892
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146893
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149350
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149351
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151212
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151351
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151394
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151395
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151396
P11362-369-unknown	MTSPLY...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152004
P11362-433-unknown	SSASMN...	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11177
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149197
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150828
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152485
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152525
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152971
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198650
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198651
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198654
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198652
P11362-433-unknown	SSASMN...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198653

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERPAVM	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22681
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130223
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130224
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132734
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132735
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134614
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134753
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134796
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134797
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134798
...ERPAVM	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135413
...TVSADS	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11177
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132582
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134230
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135896
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135936
...TVSADS	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136397
...GLKRR	822	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70729
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70727
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70725
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70723
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70737
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70721
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70731
...GLKRR	822	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70738

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_HUMAN	368	PAVM.\|.MTSP	inferred from experiment	unknown	MEROPS	Vlodavsky I	Levi E et al.:Matrix metalloproteinase 2 rele... (M10.003)	8692946,
GRAB_HUMAN	432	SADS.\|.SSAS	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)