P12023: Amyloid-beta A4 protein
Protein names | - Amyloid-beta A4 protein - ABPP - APP - Alzheimer disease amyloid A4 protein homolog - Amyloid precursor protein {ECO:0000305} - Amyloid-beta precursor protein {ECO:0000305} - Amyloidogenic glycoprotein - AG - N-APP - Soluble APP-alpha - S-APP-alpha - Soluble APP-beta - S-APP-beta - C99 - APP-C99 - Beta-secretase C-terminal fragment - Beta-CTF - Amyloid-beta protein 42 - Abeta42 - Beta-APP42 - Amyloid-beta protein 40 - Abeta40 - Beta-APP40 - C83 - Alpha-secretase C-terminal fragment - Alpha-CTF - P3(42) - P3(40) - C80 - Gamma-secretase C-terminal fragment 59 - APP-C59 - Amyloid intracellular domain 59 - AID(59) - Gamma-CTF(59) - Gamma-secretase C-terminal fragment 57 - APP-C57 - Amyloid intracellular domain 57 - AID(57) - Gamma-CTF(57) - Gamma-secretase C-terminal fragment 50 - Amyloid intracellular domain 50 - AID(50) - Gamma-CTF(50) - C31 |
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Gene names | App |
Organism | Mus musculus |
Protease Family | |
Protease ID | I02.015 |
Chromosome location | |
UniProt ID | P12023 |
13
N-termini
6
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
70 80 90 100 110 120
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
130 140 150 160 170 180
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
190 200 210 220 230 240
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
250 260 270 280 290 300
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350 360
RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD
370 380 390 400 410 420
PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
430 440 450 460 470 480
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
490 500 510 520 530 540
QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
550 560 570 580 590 600
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650 660
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
670 680 690 700 710 720
IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
730 740 750 760 770
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
Isoforms
- Isoform APP695 of Amyloid beta A4 protein - Isoform APP751 of Amyloid beta A4 protein - Isoform APP695 of Amyloid-beta A4 protein - Isoform APP751 of Amyloid-beta A4 proteinSequence View
10 20 30 40 50 60
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
70 80 90 100 110 120
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
130 140 150 160 170 180
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
190 200 210 220 230 240
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
250 260 270 280 290 300
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350 360
RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD
370 380 390 400 410 420
PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
430 440 450 460 470 480
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
490 500 510 520 530 540
QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
550 560 570 580 590 600
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650 660
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
670 680 690 700 710 720
IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
730 740 750 760 770
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
10 20 30 40 50 60
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
70 80 90 100 110 120
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
130 140 150 160 170 180
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
190 200 210 220 230 240
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
250 260 270 280 290 300
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350 360
RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD
370 380 390 400 410 420
PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
430 440 450 460 470 480
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
490 500 510 520 530 540
QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
550 560 570 580 590 600
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650 660
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
670 680 690 700 710 720
IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
730 740 750 760 770
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
10 20 30 40 50 60
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
70 80 90 100 110 120
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
130 140 150 160 170 180
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
190 200 210 220 230 240
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
250 260 270 280 290 300
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350 360
RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD
370 380 390 400 410 420
PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
430 440 450 460 470 480
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
490 500 510 520 530 540
QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
550 560 570 580 590 600
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650 660
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
670 680 690 700 710 720
IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
730 740 750 760 770
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
10 20 30 40 50 60
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
70 80 90 100 110 120
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
130 140 150 160 170 180
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
190 200 210 220 230 240
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
250 260 270 280 290 300
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350 360
RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD
370 380 390 400 410 420
PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
430 440 450 460 470 480
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
490 500 510 520 530 540
QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
550 560 570 580 590 600
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650 660
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
670 680 690 700 710 720
IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
730 740 750 760 770
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
Protein Neighborhood
Domains & Features
13 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P12023-1-unknown | MLPSLA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt65873 | |||
P12023-1-unknown | MLPSLA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt65874 | |||
P12023-18-unknown | LEVPTD... | 18 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-18-unknown | LEVPTD... | 18 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P12023-18-unknown | LEVPTD... | 18 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt112006 | |||
P12023-18-unknown | LEVPTD... | 18 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt112007 | |||
P12023-117-unknown | CLVGEF... | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160848 | |||
P12023-117-unknown | CLVGEF... | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160849 | |||
P12023-117-5oxothiomorpholine-3-carboxylic-acid | CLVGEF... | 117 | N-TAILS | Overall CM. | Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... | 20208520 | |||
P12023-166-unknown | HDYGML... | 166 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P12023-166-unknown | HDYGML... | 166 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197779 | |||
P12023-166-unknown | HDYGML... | 166 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197780 | |||
P12023-506-Pyrrolidone carboxylic acid | QHTLKH... | 506 | pyrrolidone carboxylic acid- | N-TAILS | Overall CM. | Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... | 20208520 | ||
P12023-506-Pyrrolidone carboxylic acid | QHTLKH... | 506 | pyrrolidone carboxylic acid- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160774 | ||
P12023-506-Pyrrolidone carboxylic acid | QHTLKH... | 506 | pyrrolidone carboxylic acid- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160773 | ||
P12023-672-unknown | DAEFGH... | 672 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-672-unknown | DAEFGH... | 672 | N-TAILS | Overall CM. | auf dem Keller U.: A statistics-based platform for quantitative N-terminome... | 20305283 | |||
P12023-672-unknown | DAEFGH... | 672 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116272 | |||
P12023-672-unknown | DAEFGH... | 672 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116271 | |||
P12023-688-unknown | LVFFAE... | 688 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-688-unknown | LVFFAE... | 688 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116289 | |||
P12023-688-unknown | LVFFAE... | 688 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116288 | |||
P12023-691-unknown | FAEDVG... | 691 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-691-unknown | FAEDVG... | 691 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116305 | |||
P12023-691-unknown | FAEDVG... | 691 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116304 | |||
P12023-712-unknown | IATVIV... | 712 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-712-unknown | IATVIV... | 712 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116318 | |||
P12023-712-unknown | IATVIV... | 712 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116317 | |||
P12023-712-unknown | IATVIV... | 712 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P12023-714-unknown | TVIVIT... | 714 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-714-unknown | TVIVIT... | 714 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116329 | |||
P12023-714-unknown | TVIVIT... | 714 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116328 | |||
P12023-714-unknown | TVIVIT... | 714 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P12023-721-unknown | VMLKKK... | 721 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-721-unknown | VMLKKK... | 721 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116340 | |||
P12023-721-unknown | VMLKKK... | 721 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116339 | |||
P12023-740-unknown | AAVTPE... | 740 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P12023-740-unknown | AAVTPE... | 740 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116366 | |||
P12023-740-unknown | AAVTPE... | 740 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116365 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SVEEVV | 286 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SVEEVV | 286 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92230 | |||
...SVEEVV | 286 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92231 | |||
...SEVKMD | 671 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SEVKMD | 671 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93206 | |||
...SEVKMD | 671 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93205 | |||
...VRHQKL | 687 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VRHQKL | 687 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93240 | |||
...VRHQKL | 687 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93239 | |||
...VGGVVI | 711 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VGGVVI | 711 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93294 | |||
...VGGVVI | 711 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93293 | |||
...GVVIAT | 713 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GVVIAT | 713 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93306 | |||
...GVVIAT | 713 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93305 | |||
...EQMQN | 770 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EQMQN | 770 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt61491 | |||
...EQMQN | 770 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt61492 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|