P13489: Ribonuclease inhibitor

General Information

Protein names	- Ribonuclease inhibitor - Placental ribonuclease inhibitor - Placental RNase inhibitor - Ribonuclease/angiogenin inhibitor 1 - RAI
Gene names	RNH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13489

10 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL TEARCKDISS ALRVNPALAE
        70         80         90        100        110        120
LNLRSNELGD VGVHCVLQGL QTPSCKIQKL SLQNCCLTGA GCGVLSSTLR TLPTLQELHL
       130        140        150        160        170        180
SDNLLGDAGL QLLCEGLLDP QCRLEKLQLE YCSLSAASCE PLASVLRAKP DFKELTVSNN
       190        200        210        220        230        240
DINEAGVRVL CQGLKDSPCQ LEALKLESCG VTSDNCRDLC GIVASKASLR ELALGSNKLG
       250        260        270        280        290        300
DVGMAELCPG LLHPSSRLRT LWIWECGITA KGCGDLCRVL RAKESLKELS LAGNELGDEG
       310        320        330        340        350        360
ARLLCETLLE PGCQLESLWV KSCSFTAACC SHFSSVLAQN RFLLELQISN NRLEDAGVRE
       370        380        390        400        410        420
LCQGLGQPGS VLRVLWLADC DVSDSSCSSL AATLLANHSL RELDLSNNCL GDAGILQLVE
       430        440        450        460
SVRQPGCLLE QLVLYDIYWS EEMEDRLQAL EKDKPSLRVI S

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13489-2-unknown	MSLDIQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13489-2-Acetylation	SLDIQS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13489-2-Acetylation	SLDIQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P13489-2-Acetylation	SLDIQS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P13489-2-Acetylation	SLDIQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P13489-2-Acetylation	SLDIQS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-7-	SLDIQC...	7			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-9-	DIQCEE...	9			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-54-	VNPALA...	54			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-54-acetylation	VNPALA...	54	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-128-unknown	AGLQLL...	128		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11199
P13489-153-	SLSAAS...	153			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P13489-207-unknown	ESCGVT...	207		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432170
P13489-290-	SLAGNE...	290			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDCGLT	40	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434971
...NLLGDA	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11199
...AGVRVL	189	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434947
...LCQGLK	194	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435057
...KDSPCQ	199	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435748
...LRVIS	461	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	127	LGDA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)