P13861: cAMP-dependent protein kinase type II-alpha regulatory subunit

General Information

Protein names	- cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene names	PRKAR2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13861

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG
        70         80         90        100        110        120
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH
       130        140        150        160        170        180
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE
       190        200        210        220        230        240
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI
       250        260        270        280        290        300
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI
       310        320        330        340        350        360
IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL
       370        380        390        400
VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ

Isoforms

- Isoform 2 of cAMP-dependent protein kinase type II-alpha regulatory subunit

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P13861-2-unknown	MSHIQI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13861-2-Acetylation	SHIQIP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13861-2-Acetylation	SHIQIP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P13861-61-unknown	HPPPEP...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17332
P13861-104-unknown	TYNPDE...	104		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11210

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RQSLGH	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17332
...SVCAET	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11210
...KTDEQR	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411432
...GNLGQ	404	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	60	SLGH.\|.HPPP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	103	CAET.\|.TYNP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)