P14136: Glial fibrillary acidic protein

General Information

Protein names	- Glial fibrillary acidic protein - GFAP
Gene names	GFAP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14136

6 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Glial fibrillary acidic protein - Isoform 3 of Glial fibrillary acidic protein

Sequence View

        10         20         30         40         50         60
MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA
        70         80         90        100        110        120
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
       130        140        150        160        170        180
RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKLQDETN LRLEAENNLA AYRQEADEAT
       190        200        210        220        230        240
LARLDLERKI ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDVAKPD LTAALKEIRT
       250        260        270        280        290        300
QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR
       310        320        330        340        350        360
GTNESLERQM REQEERHVRE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD
       370        380        390        400        410        420
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
       430
IKESKQEHKD VM         10         20         30         40         50         60
MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA
        70         80         90        100        110        120
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
       130        140        150        160        170        180
RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKLQDETN LRLEAENNLA AYRQEADEAT
       190        200        210        220        230        240
LARLDLERKI ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDVAKPD LTAALKEIRT
       250        260        270        280        290        300
QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR
       310        320        330        340        350        360
GTNESLERQM REQEERHVRE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD
       370        380        390        400        410        420
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
       430
IKESKQEHKD VM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P14136-1-unknown	MERRRI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P14136-1-unknown	MERRRI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75891
P14136-1-unknown	MERRRI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75892
P14136-143-unknown	NLAQDL...	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2530
P14136-143-unknown	NLAQDL...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144461
P14136-143-unknown	NLAQDL...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144462
P14136-178-unknown	EATLAR...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2533
P14136-178-unknown	EATLAR...	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145842
P14136-178-unknown	EATLAR...	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145843
P14136-226-unknown	VAKPDL...	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2536
P14136-226-unknown	VAKPDL...	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147606
P14136-226-unknown	VAKPDL...	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147607
P14136-234-unknown	ALKEIR...	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9991
P14136-234-unknown	ALKEIR...	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147857
P14136-234-unknown	ALKEIR...	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147859
P14136-267-unknown	AAARNA...	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1654
P14136-267-unknown	AAARNA...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149048
P14136-267-unknown	AAARNA...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149049

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVERDN	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2530
...EVERDN	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127725
...EVERDN	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127726
...RQEADE	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2533
...RQEADE	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129139
...RQEADE	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129140
...HVELDV	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2536
...HVELDV	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130958
...HVELDV	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130959
...PDLTAA	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9991
...PDLTAA	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131212
...PDLTAA	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131214
...ADLTDA	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1654
...ADLTDA	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132432
...ADLTDA	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132433
...HKDVM	432	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	142	ERDN.\|.NLAQ	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	177	EADE.\|.EATL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	225	ELDV.\|.VAKP	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
GRAA_HUMAN	233	LTAA.\|.ALKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CASP3_HUMAN	266	LTDA.\|.AAAR	inferred from experiment	unknown	MEROPS	Rohn TT	Mouser PE et al.:Caspase-mediated cleavage of gl... (C14.003)	16507909,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)