P16104: Histone H2AX

General Information

Protein names	- Histone H2AX - H2a/x - Histone H2A.X
Gene names	H2AFX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16104

6 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT
        70         80         90        100        110        120
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK
       130        140
TSATVGPKAP SGGKKATQAS QEY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P16104-2-unknown	MSGRGK...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P16104-2-unknown	MSGRGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P16104-2-Acetylation	SGRGKT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P16104-2-Acetylation	SGRGKT...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P16104-22-unknown	AGLQFP...	22		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9994
P16104-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9995
P16104-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13980
P16104-61-unknown	AEILEL...	61		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9996
P16104-83-unknown	HLQLAI...	83		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9997

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRSSRA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9994
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9995
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13980
...LEYLTA	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9996
...RIIPRH	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9997
...ASQEY	143	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	21	SSRA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	60	YLTA.\|.AEIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	82	IPRH.\|.HLQL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)