P17096: High mobility group protein HMG-I/HMG-Y

General Information

Protein names	- High mobility group protein HMG-I/HMG-Y - HMG-I(Y) - High mobility group AT-hook protein 1 - High mobility group protein A1 - High mobility group protein R
Gene names	HMGA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17096

11 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR
70 80 90 100
PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ

Isoforms

- Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y - Isoform HMG-R of High mobility group protein HMG-I/HMG-Y

Sequence View

        10         20         30         40         50         60
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR
        70         80         90        100
PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ         10         20         30         40         50         60
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR
        70         80         90        100
PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17096-2-unknown	MSESSS...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P17096-2-unknown	MSESSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17096-1-unknown	MSESSS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77077
P17096-1-unknown	MSESSS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77078
P17096-2-Acetylation	SESSSK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17096-2-Acetylation	SESSSK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P17096-2-Acetylation	SESSSK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P17096-2-Acetylation	SESSSK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110321
P17096-2-Acetylation	SESSSK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110322
P17096-2-Acetylation	SESSSK...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P17096-13-unknown	ASKQEK...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14009
P17096-13-unknown	ASKQEK...	13		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136448
P17096-13-unknown	ASKQEK...	13		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136449
P17096-42-	VGSQKE...	42			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P17096-42-	VGSQKE...	42			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P17096-42-unknown	VGSQKE...	42			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P17096-42-unknown	VGSQKE...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159720
P17096-44-unknown	SQKEPS...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172697
P17096-44-	SQKEPS...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17096-44-	SQKEPS...	44			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P17096-50-unknown	EVPTPK...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14012
P17096-50-unknown	EVPTPK...	50		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196136
P17096-89-	KLEKEE...	89			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P17096-89-unknown	KLEKEE...	89		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177439

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSQPLA	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14009
...QKEPSE	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14012
...QKEPSE	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122275
...SEEEQ	107	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SEEEQ	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72695

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	12	QPLA.\|.ASKQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	49	EPSE.\|.EVPT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)