P18031: Tyrosine-protein phosphatase non-receptor type 1

General Information

Protein names	- Tyrosine-protein phosphatase non-receptor type 1 - 3.1.3.48 - Protein-tyrosine phosphatase 1B - PTP-1B
Gene names	PTPN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18031

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH
        70         80         90        100        110        120
QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK
       130        140        150        160        170        180
CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP
       190        200        210        220        230        240
DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD
       250        260        270        280        290        300
PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE
       310        320        330        340        350        360
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG
       370        380        390        400        410        420
IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT
       430
AGAYLCYRFL FNSNT

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18031-1-Acetylation	MEMEKE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18031-74-unknown	MEEAQR...	74		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437732
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P18031-356-	AAPYGI...	356			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...FNSNT	435	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)