P18065: Insulin-like growth factor-binding protein 2

General Information

Protein names	- Insulin-like growth factor-binding protein 2 - IBP-2 - IGF-binding protein 2 - IGFBP-2
Gene names	IGFBP2
Organism	Homo sapiens
Protease Family
Protease ID	I31.953
Chromosome location
UniProt ID	P18065

6 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL AACGPPPVAP
        70         80         90        100        110        120
PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV YTPRCGQGLR CYPHPGSELP
       130        140        150        160        170        180
LQALVMGEGT CEKRRDAEYG ASPEQVADNG DDHSEGGLVE NHVDSTMNML GGGGSAGRKP
       190        200        210        220        230        240
LKSGMKELAV FREKVTEQHR QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST
       250        260        270        280        290        300
MRLPDERGPL EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
       310        320
RGDPECHLFY NEQQEARGVH TQRMQ

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P18065-36-unknown	AEVLFR...	36	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P18065-36-unknown	AEVLFR...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16452
P18065-167-unknown	MNMLGG...	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401698
P18065-188-unknown	LAVFRE...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24726
P18065-201-unknown	QMGKGG...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16453
P18065-201-unknown	QMGKGG...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16084
P18065-212-unknown	LEEPKK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24727
P18065-218-unknown	LRPPPA...	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24728

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGGARA	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16452
...SGMKEL	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24726
...TEQHRQ	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16453
...TEQHRQ	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16084
...KHHLGL	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24727
...EEPKKL	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24728
...TMRLPD	244	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401698
...TQRMQ	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	35	GARA.\|.AEVL	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
MMP7_HUMAN	187	MKEL.\|.LAVF	inferred from experiment	unknown	MEROPS	Ochiai A	Miyamoto S et al.:Matrix metalloproteinase-7 trig... (M10.008)	17359288,
KLK5_HUMAN	200	QHRQ.\|.QMGK	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
KLK2_HUMAN	200	QHRQ.\|.QMGK	inferred from experiment	unknown	MEROPS	Moreau T	Rehault S et al.:Insulin-like growth factor bind... (S01.161)	11358513,
MMP7_HUMAN	211	HLGL.\|.LEEP	inferred from experiment	unknown	MEROPS	Ochiai A	Miyamoto S et al.:Matrix metalloproteinase-7 trig... (M10.008)	17359288,
MMP7_HUMAN	217	PKKL.\|.LRPP	inferred from experiment	unknown	MEROPS	Ochiai A	Miyamoto S et al.:Matrix metalloproteinase-7 trig... (M10.008)	17359288,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)