P20248: Cyclin-A2 {ECO:0000312|HGNC:HGNC:1578}

General Information

Protein names	- Cyclin-A2 {ECO:0000312\|HGNC:HGNC:1578} - Cyclin-A {ECO:0000303\|PubMed:1967822} - Cyclin A {ECO:0000303\|PubMed:1967822}
Gene names	CCNA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20248

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLGNSAPGPA TREAGSALLA LQQTALQEDQ ENINPEKAAP VQQPRTRAAL AVLKSGNPRG
        70         80         90        100        110        120
LAQQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEKEA QKKPAESQKI
       130        140        150        160        170        180
EREDALAFNS AISLPGPRKP LVPLDYPMDG SFESPHTMDM SIILEDEKPV SVNEVPDYHE
       190        200        210        220        230        240
DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID
       250        260        270        280        290        300
RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK
       310        320        330        340        350        360
VLTFDLAAPT VNQFLTQYFL HQQPANCKVE SLAMFLGELS LIDADPYLKY LPSVIAGAAF
       370        380        390        400        410        420
HLALYTVTGQ SWPESLIRKT GYTLESLKPC LMDLHQTYLK APQHAQQSIR EKYKNSKYHG
       430
VSLLNPPETL NL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P20248-1-unknown	MLGNSA...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P20248-1-Acetylation	MLGNSA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20248-1-Acetylation	MLGNSA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P20248-1-Acetylation	MLGNSA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P20248-1-	MLGNSA...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P20248-5-	SAPGPA...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ETLNL	432	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)