P21127: Cyclin-dependent kinase 11B

General Information

Protein names	- Cyclin-dependent kinase 11B - 2.7.11.22 - Cell division cycle 2-like protein kinase 1 - CLK-1 - Cell division protein kinase 11B - Galactosyltransferase-associated protein kinase p58/GTA - PITSLRE serine/threonine-protein kinase CDC2L1 - p58 CLK-1
Gene names	CDK11B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P21127

8 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SV1 of Cyclin-dependent kinase 11B - Isoform 2 of Cyclin-dependent kinase 11B - Isoform 3 of Cyclin-dependent kinase 11B - Isoform SV4 of Cyclin-dependent kinase 11B - Isoform SV5 of Cyclin-dependent kinase 11B - Isoform 8 of Cyclin-dependent kinase 11B - Isoform SV10 of Cyclin-dependent kinase 11B - Isoform SV11 of Cyclin-dependent kinase 11B - Isoform 7 of Cyclin-dependent kinase 11B - Isoform SV1 of Cyclin-dependent kinase 11B - Isoform 2 of Cyclin-dependent kinase 11B - Isoform SV5 of Cyclin-dependent kinase 11B - Isoform 8 of Cyclin-dependent kinase 11B - Isoform SV10 of Cyclin-dependent kinase 11B

Sequence View

        10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF         10         20         30         40         50         60
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI
        70         80         90        100        110        120
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK
       130        140        150        160        170        180
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK
       190        200        210        220        230        240
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR
       250        260        270        280        290        300
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
       310        320        330        340        350        360
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED
       370        380        390        400        410        420
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ
       430        440        450        460        470        480
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI
       490        500        510        520        530        540
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK
       550        560        570        580        590        600
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
       610        620        630        640        650        660
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK
       670        680        690        700        710        720
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH
       730        740        750        760        770        780
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT
       790
NQGASAAGPG FSLKF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P21127-1-unknown	MGDEKD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21127-1-unknown	MGDEKD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69856
P21127-1-unknown	MGDEKD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69857
P21127-1-unknown	MGDEKD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69861
P21127-2-unknown	GDEKDS...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P21127-2-unknown	GDEKDS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178929
P21127-2-unknown	GDEKDS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178930
P21127-2-unknown	GDEKDS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178931
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69859
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108504
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108502
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108503
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108505
P21127-270-unknown	MEERDL...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108506
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P21127-406-	YVPDSP...	406		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P21127-406-unknown	YVPDSP...	406		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161356
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161355
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161354
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161352
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161353
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161357
P21127-406-unknown	YVPDSP...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161358
P21127-410-unknown	SPALSP...	410	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1187
P21127-410-unknown	SPALSP...	410	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1721
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141063
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144369
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151014
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151255
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151781
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151945
P21127-410-unknown	SPALSP...	410	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151956
P21127-788-	GPGFSL...	788		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175463
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175462
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175461
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175459
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175460
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175464
P21127-788-unknown	GPGFSL...	788	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175465

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DYVPDS	409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1187
...DYVPDS	409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1721
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124214
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127631
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134417
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134656
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135185
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135353
...DYVPDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135364
...FSLKF	795	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65476
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65477
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65478
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65480
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65479
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65475
...FSLKF	795	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65474

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	409	VPDS.\|.SPAL	inferred from experiment	unknown	MEROPS	Fiers W	Beyaert R et al.:Cleavage of PITSLRE kinases by ... (C14.001)	9115219,
CASP3_HUMAN	409	VPDS.\|.SPAL	inferred from experiment	unknown	MEROPS	Fiers W	Beyaert R et al.:Cleavage of PITSLRE kinases by ... (C14.001)	9115219,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)