P22830: Ferrochelatase, mitochondrial

General Information

Protein names	- Ferrochelatase, mitochondrial - 4.99.1.1 - Heme synthase - Protoheme ferro-lyase
Gene names	FECH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22830

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSLGANMAA ALRAAGVLLR DPLASSSWRV CQPWRWKSGA AAAAVTTETA QHAQGAKPQV
        70         80         90        100        110        120
QPQKRKPKTG ILMLNMGGPE TLGDVHDFLL RLFLDRDLMT LPIQNKLAPF IAKRRTPKIQ
       130        140        150        160        170        180
EQYRRIGGGS PIKIWTSKQG EGMVKLLDEL SPNTAPHKYY IGFRYVHPLT EEAIEEMERD
       190        200        210        220        230        240
GLERAIAFTQ YPQYSCSTTG SSLNAIYRYY NQVGRKPTMK WSTIDRWPTH HLLIQCFADH
       250        260        270        280        290        300
ILKELDHFPL EKRSEVVILF SAHSLPMSVV NRGDPYPQEV SATVQKVMER LEYCNPYRLV
       310        320        330        340        350        360
WQSKVGPMPW LGPQTDESIK GLCERGRKNI LLVPIAFTSD HIETLYELDI EYSQVLAKEC
       370        380        390        400        410        420
GVENIRRAES LNGNPLFSKA LADLVHSHIQ SNELCSKQLT LSCPLCVNPV CRETKSFFTS

QQL

Isoforms

- Isoform 2 of Ferrochelatase, mitochondrial

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22830-1-unknown	MRSLGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76913
P22830-43-unknown	AAVTTE...	43		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P22830-43-unknown	AAVTTE...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161629
P22830-43-	AAVTTE...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P22830-43-	AAVTTE...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22830-44-	AVTTET...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22830-44-unknown	AVTTET...	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171780
P22830-55-unknown	GAKPQV...	55	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22830-56-unknown	AKPQVQ...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7378

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QHAQGA	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7378
...QHAQGA	55	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122714
...TSQQL	423		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TSQQL	423		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TSQQL	423	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TSQQL	423	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt72531
...TSQQL	423		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TSQQL	423		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	55	AQGA.\|.AKPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)