P23634: Plasma membrane calcium-transporting ATPase 4 {ECO:0000305}

General Information

Protein names	- Plasma membrane calcium-transporting ATPase 4 {ECO:0000305} - PMCA4 {ECO:0000303\|PubMed:1531651, ECO:0000312\|EMBL:AAA50819.1} - 7.2.2.10 {ECO:0000269\|PubMed:8530416} - Matrix-remodeling-associated protein 1 - Plasma membrane calcium ATPase isoform 4 - Plasma membrane calcium pump isoform 4
Gene names	ATP2B4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23634

7 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform XA of Plasma membrane calcium-transporting ATPase 4 - Isoform ZA of Plasma membrane calcium-transporting ATPase 4 - Isoform XK of Plasma membrane calcium-transporting ATPase 4 - Isoform ZK of Plasma membrane calcium-transporting ATPase 4 - Isoform XB of Plasma membrane calcium-transporting ATPase 4 - Isoform ZB of Plasma membrane calcium-transporting ATPase 4 - Isoform ZD of Plasma membrane calcium-transporting ATPase 4

Sequence View

        10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V         10         20         30         40         50         60
MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT
        70         80         90        100        110        120
SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS
       130        140        150        160        170        180
FYRPAGEENE LCGQVATTPE DENEAQAGWI EGAAILFSVI IVVLVTAFND WSKEKQFRGL
       190        200        210        220        230        240
QCRIEQEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT
       250        260        270        280        290        300
GESDHVKKSL DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIILTLLGVN EDDEGEKKKK
       310        320        330        340        350        360
GKKQGVPENR NKAKTQDGVA LEIQPLNSQE GIDNEEKDKK AVKVPKKEKS VLQGKLTRLA
       370        380        390        400        410        420
VQIGKAGLLM SALTVFILIL YFVIDNFVIN RRPWLPECTP IYIQYFVKFF IIGITVLVVA
       430        440        450        460        470        480
VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA
       490        500        510        520        530        540
YIGGIHYRQI PSPDVFLPKV LDLIVNGISI NSAYTSKILP PEKEGGLPRQ VGNKTECALL
       550        560        570        580        590        600
GFVTDLKQDY QAVRNEVPEE KLYKVYTFNS VRKSMSTVIR NPNGGFRMYS KGASEIILRK
       610        620        630        640        650        660
CNRILDRKGE AVPFKNKDRD DMVRTVIEPM ACDGLRTICI AYRDFDDTEP SWDNENEILT
       670        680        690        700        710        720
ELTCIAVVGI EDPVRPEVPD AIAKCKQAGI TVRMVTGDNI NTARAIATKC GILTPGDDFL
       730        740        750        760        770        780
CLEGKEFNRL IRNEKGEVEQ EKLDKIWPKL RVLARSSPTD KHTLVKGIID STVGEHRQVV
       790        800        810        820        830        840
AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI
       850        860        870        880        890        900
SKFLQFQLTV NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTESLL
       910        920        930        940        950        960
KRRPYGRNKP LISRTMMKNI LGHAFYQLIV IFILVFAGEK FFDIDSGRKA PLHSPPSQHY
       970        980        990       1000       1010       1020
TIVFNTFVLM QLFNEINSRK IHGEKNVFSG IYRNIIFCSV VLGTFICQIF IVEFGGKPFS
      1030       1040       1050       1060       1070       1080
CTSLSLSQWL WCLFIGIGEL LWGQFISAIP TRSLKFLKEA GHGTTKEEIT KDAEGLDEID
      1090       1100       1110       1120       1130       1140
HAEMELRRGQ ILWFRGLNRI QTQIDVINTF QTGASFKGVL RRQNMGQHLD VKLVPSSSYI
      1150       1160       1170       1180       1190       1200
KVVKAFHSSL HESIQKPYNQ KSIHSFMTHP EFAIEEELPR TPLLDEEEEE NPDKASKFGT
      1210       1220       1230       1240
RVLLLDGEVT PYANTNNNAV DCNQVQLPQS DSSLQSLETS V

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P23634-1-unknown	MTNPSD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67777
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67778
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67779
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67780
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67781
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67782
P23634-1-unknown	MTNPSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67783
P23634-1081-unknown	HAEMEL...	1081	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1197
P23634-1081-unknown	HAEMEL...	1081	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1740
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157235
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157262
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157296
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157297
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157298
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157329
P23634-1081-unknown	HAEMEL...	1081	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157330
P23634-1081-	HAEMEL...	1081		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P23634-1165-unknown	SFMTHP...	1165		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P23634-1165-unknown	SFMTHP...	1165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159431
P23634-1165-unknown	SFMTHP...	1165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159432
P23634-1165-unknown	SFMTHP...	1165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159430
P23634-1165-	SFMTHP...	1165		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P23634-1165-	SFMTHP...	1165		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P23634-1165-	SFMTHP...	1165		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P23634-1165-	SFMTHP...	1165		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P23634-1165-	SFMTHP...	1165		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P23634-1167-unknown	MTHPEF...	1167		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P23634-1167-unknown	MTHPEF...	1167	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159435
P23634-1167-unknown	MTHPEF...	1167	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159436
P23634-1167-unknown	MTHPEF...	1167	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159434
P23634-1167-	MTHPEF...	1167		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P23634-1167-	MTHPEF...	1167		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDEIDH	1080	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1197
...LDEIDH	1080	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1740
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140733
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140761
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140795
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140796
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140797
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140828
...LDEIDH	1080	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140829
...LETSV	1241	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LETSV	1241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63400
...LETSV	1241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63399
...LETSV	1241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63401

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	1080	EIDH.\|.HAEM	inferred from experiment	unknown	MEROPS	Enyedi A	Paszty K et al.:Asp1080 upstream of the calmodu... (C14.001)	12145294,
CASP3_HUMAN	1080	EIDH.\|.HAEM	inferred from experiment	unknown	MEROPS	Enyedi A	Paszty K et al.:Asp1080 upstream of the calmodu... (C14.001)	12145294,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)