P25206: DNA replication licensing factor MCM3

General Information

Protein names	- DNA replication licensing factor MCM3 - 3.6.4.12 - DNA polymerase alpha holoenzyme-associated protein P1 - P1-MCM3
Gene names	Mcm3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P25206

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQNKVRELI SDNQYRLIVS VNDLRRKNEK
        70         80         90        100        110        120
RANRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYI GLEGSFGSKH VSPRTLTSCF
       130        140        150        160        170        180
LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA TKKTIERRYS DLTTLVAFPS SSVYPTKDEE
       190        200        210        220        230        240
NNPLETEYGL SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKVK PGDRIQVVGT
       250        260        270        280        290        300
YRCLPGKKGC YTSGTFRTVL IACNVKQMSK DIQPAFSADD IAKIKKFSKT RSKDVFEQLA
       310        320        330        340        350        360
RSLAPSIHGH DYVKKAILCL LLGGVERELE NGSHIRGDIN ILLIGDPSVA KSQLLRYVLC
       370        380        390        400        410        420
TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL ADRGVVCIDE FDKMSDMDRT
       430        440        450        460        470        480
AIHEVMEQGR VTIAKAGIHA RLNARCSVLA AANPVYGRYD QYKTPMENIG LQDSLLSRFD
       490        500        510        520        530        540
LLFIMLDQMD PEQDREISDH VLRMHQYRAP GEQDGDALPL GSSVDILATD DPDFTQDDQQ
       550        560        570        580        590        600
DTRIYEKHDS LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP TLTQESAAYI AEEYSRLRSQ
       610        620        630        640        650        660
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ YAYFKKVLEK
       670        680        690        700        710        720
EKKRKKASED ESDLEDEEEK SQEDTEQKRK RRKTHAKDGE SYDPYDFSEA ETQMPQVHTP
       730        740        750        760        770        780
KTDDSQEKTD DSQETQDSQK VELSEPRLKA FKAALLEVFQ EAHEQSVGML HLTESINRNR
       790        800        810
EEPFSSEEIQ ACLSRMQDDN QVMVSEGIVF LI

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P25206-2-unknown	MAGTVV...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P25206-2-unknown	MAGTVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P25206-2-Acetylation	AGTVVL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P25206-2-Acetylation	AGTVVL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P25206-8-unknown	DDVELR...	8		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P25206-517-unknown	ALPLGS...	517		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32327
P25206-526-unknown	ILATDD...	526		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32328
P25206-531-unknown	DPDFTQ...	531		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28350
P25206-534-unknown	FTQDDQ...	534		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28351
P25206-738-unknown	SQKVEL...	738		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32329

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EQDGDA	516	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32327
...GSSVDI	525	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32328
...ILATDD	530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28350
...TDDPDF	533	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28351
...QETQDS	737	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32329
...IVFLI	812	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	516	DGDA.\|.ALPL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_MOUSE	525	SVDI.\|.ILAT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_MOUSE	530	ATDD.\|.DPDF	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP1_MOUSE	533	DPDF.\|.FTQD	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
GRAB_MOUSE	737	TQDS.\|.SQKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)