P25786: Proteasome subunit alpha type-1

General Information

Protein names	- Proteasome subunit alpha type-1 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - 30 kDa prosomal protein - PROS-30 - Macropain subunit C2 - Multicatalytic endopeptidase complex subunit C2 - Proteasome component C2 - Proteasome nu chain
Gene names	PSMA1
Organism	Homo sapiens
Protease Family
Protease ID	T01.976
Chromosome location
UniProt ID	P25786

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ
        70         80         90        100        110        120
KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT
       130        140        150        160        170        180
QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM
       190        200        210        220        230        240
ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP
       250        260
QRKAQPAQPA DEPAEKADEP MEH

Isoforms

- Isoform Long of Proteasome subunit alpha type-1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25786-1-Acetylation	MFRNQY...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25786-1-Acetylation	MFRNQY...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25786-4-acetylation	NQYDND...	4	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25786-4-acetylation	NQYDND...	4	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182565
P25786-108-acetylation	LVSLIG...	108	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25786-108-acetylation	LVSLIG...	108	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182563
P25786-181-unknown	ECNLNE...	181		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7387
P25786-181-unknown	ECNLNE...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146160
P25786-243-	KAQPAQ...	243			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25786-243-unknown	KAQPAQ...	243		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169485

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MSEFME	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7387
...MSEFME	180	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129463
...EPMEH	263	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EPMEH	263	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81959
...EPMEH	263		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EPMEH	263		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	180	EFME.\|.ECNL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)