P25789: Proteasome subunit alpha type-4

General Information

Protein names	- Proteasome subunit alpha type-4 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain subunit C9 - Multicatalytic endopeptidase complex subunit C9 - Proteasome component C9 - Proteasome subunit L
Gene names	PSMA4
Organism	Homo sapiens
Protease Family
Protease ID	T01.973
Chromosome location
UniProt ID	P25789

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF
        70         80         90        100        110        120
FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA
       130        140        150        160        170        180
YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK
       190        200        210        220        230        240
EGEMTLKSAL ALAIKVLNKT MDVSKLSAEK VEIATLTREN GKTVIRVLKQ KEVEQLIKKH
       250        260
EEEEAKAERE KKEKEQKEKD K

Isoforms

- Isoform 2 of Proteasome subunit alpha type-4

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P25789-1-unknown	MSRRYD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25789-72-unknown	MACSVA...	72	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86344
P25789-81-unknown	SDANVL...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182573
P25789-81-	SDANVL...	81		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25789-83-unknown	ANVLTN...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11363
P25789-83-unknown	ANVLTN...	83	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136362

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GITSDA	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11363
...KEKDK	261	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KEKDK	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81962
...KEKDK	261		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEKDK	261		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KEKDK	261		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEKDK	261		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	82	TSDA.\|.ANVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)