P26583: High mobility group protein B2

General Information

Protein names	- High mobility group protein B2 - High mobility group protein 2 - HMG-2
Gene names	HMGB2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P26583

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF
        70         80         90        100        110        120
EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL
       130        140        150        160        170        180
SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG
       190        200
SKKKNEPEDE EEEEEEEDED EEEEDEDEE

Isoforms

Sequence View

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26583-1-acetylation	MGKGDP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P26583-1-acetylation	MGKGDP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26583-2-unknown	GKGDPN...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26583-2-unknown	GKGDPN...	2		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P26583-2-unknown	GKGDPN...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P26583-2-unknown	GKGDPN...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26583-2-	GKGDPN...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26583-35-	SVNFAE...	35			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P26583-66-unknown	SDKARY...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10045

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDMAKS	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10045
...GEMWSE	134	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423001
...DEDEE	209	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	65	MAKS.\|.SDKA	inferred from experiment	unknown	MEROPS	Lieberman J	Fan Z et al.:HMG2 interacts with the nucleos... (S01.135)	11909973,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)