P30837: Aldehyde dehydrogenase X, mitochondrial

General Information

Protein names	- Aldehyde dehydrogenase X, mitochondrial - 1.2.1.3 - Aldehyde dehydrogenase 5 - Aldehyde dehydrogenase family 1 member B1
Gene names	ALDH1B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30837

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT
        70         80         90        100        110        120
TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNLLAD LVERDRVYLA
       130        140        150        160        170        180
SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG
       190        200        210        220        230        240
QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG
       250        260        270        280        290        300
YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM
       310        320        330        340        350        360
EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP
       370        380        390        400        410        420
QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP
       430        440        450        460        470        480
VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT
       490        500        510
PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30837-18-unknown	RYSSAA...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30837-21-	SAAALP...	21		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30837-21-	SAAALP...	21		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30837-41-	INNEWQ...	41		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30837-262-unknown	GSTEVG...	262	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7418
P30837-263-unknown	STEVGH...	263	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7419
P30837-298-unknown	ADMEHA...	298	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11439

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVAFTG	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7418
...VAFTGS	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7419
...IVLADA	297	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11439
...PQKNS	517	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	261	AFTG.\|.GSTE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	262	FTGS.\|.STEV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	297	LADA.\|.ADME	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)