P33316: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

General Information

Protein names	- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial - dUTPase - 3.6.1.23 - dUTP pyrophosphatase
Gene names	DUT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P33316

10 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ HGIPRPLSSA
        70         80         90        100        110        120
GRLSQGCRGA STVGAAGWKG ELPKAGGSPA PGPETPAISP SKRARPAEVG GMQLRFARLS
       130        140        150        160        170        180
EHATAPTRGS ARAAGYDLYS AYDYTIPPME KAVVKTDIQI ALPSGCYGRV APRSGLAAKH
       190        200        210        220        230        240
FIDVGAGVID EDYRGNVGVV LFNFGKEKFE VKKGDRIAQL ICERIFYPEI EEVQALDDTE
       250
RGSGGFGSTG KN

Isoforms

- Isoform 2 of Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P33316-70-unknown	ASTVGA...	70	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33316-70-unknown	ASTVGA...	70		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33316-70-unknown	ASTVGA...	70		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P33316-70-	ASTVGA...	70		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P33316-71-	STVGAA...	71		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33316-71-	STVGAA...	71		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P33316-72-	TVGAAG...	72		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33316-84-	KAGGSP...	84		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33316-112-unknown	MQLRFA...	112	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000453717
P33316-112-unknown	MQLRFA...	112	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197135
P33316-140-	SAYDYT...	140		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P33316-140-unknown	SAYDYT...	140	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176935
P33316-242-	GSGGFG...	242		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P33316-242-unknown	GSGGFG...	242		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33316-242-unknown	GSGGFG...	242	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161483
P33316-242-unknown	GSGGFG...	242	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33316-242-unknown	GSGGFG...	242	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QALDDT	238	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000453683
...ERGSGG	244	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452749
...STGKN	252		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...STGKN	252		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...STGKN	252	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...STGKN	252	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68988
...STGKN	252		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...STGKN	252		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)