P35611: Alpha-adducin

General Information

Protein names	- Alpha-adducin - Erythrocyte adducin subunit alpha
Gene names	ADD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35611

15 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Alpha-adducin - Isoform 3 of Alpha-adducin - Isoform 4 of Alpha-adducin - Isoform 5 of Alpha-adducin - Isoform 6 of Alpha-adducin

Sequence View

        10         20         30         40         50         60
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
        70         80         90        100        110        120
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS
       130        140        150        160        170        180
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF
       190        200        210        220        230        240
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI
       250        260        270        280        290        300
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
       310        320        330        340        350        360
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV
       370        380        390        400        410        420
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS
       430        440        450        460        470        480
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT
       490        500        510        520        530        540
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT
       550        560        570        580        590        600
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
       610        620        630        640        650        660
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK
       670        680        690        700        710        720
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK
       730
KFRTPSFLKK SKKKSDS         10         20         30         40         50         60
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
        70         80         90        100        110        120
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS
       130        140        150        160        170        180
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF
       190        200        210        220        230        240
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI
       250        260        270        280        290        300
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
       310        320        330        340        350        360
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV
       370        380        390        400        410        420
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS
       430        440        450        460        470        480
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT
       490        500        510        520        530        540
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT
       550        560        570        580        590        600
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
       610        620        630        640        650        660
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK
       670        680        690        700        710        720
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK
       730
KFRTPSFLKK SKKKSDS         10         20         30         40         50         60
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
        70         80         90        100        110        120
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS
       130        140        150        160        170        180
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF
       190        200        210        220        230        240
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI
       250        260        270        280        290        300
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
       310        320        330        340        350        360
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV
       370        380        390        400        410        420
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS
       430        440        450        460        470        480
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT
       490        500        510        520        530        540
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT
       550        560        570        580        590        600
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
       610        620        630        640        650        660
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK
       670        680        690        700        710        720
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK
       730
KFRTPSFLKK SKKKSDS         10         20         30         40         50         60
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
        70         80         90        100        110        120
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS
       130        140        150        160        170        180
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF
       190        200        210        220        230        240
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI
       250        260        270        280        290        300
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
       310        320        330        340        350        360
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV
       370        380        390        400        410        420
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS
       430        440        450        460        470        480
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT
       490        500        510        520        530        540
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT
       550        560        570        580        590        600
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
       610        620        630        640        650        660
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK
       670        680        690        700        710        720
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK
       730
KFRTPSFLKK SKKKSDS         10         20         30         40         50         60
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM
        70         80         90        100        110        120
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS
       130        140        150        160        170        180
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF
       190        200        210        220        230        240
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI
       250        260        270        280        290        300
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
       310        320        330        340        350        360
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV
       370        380        390        400        410        420
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS
       430        440        450        460        470        480
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT
       490        500        510        520        530        540
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT
       550        560        570        580        590        600
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
       610        620        630        640        650        660
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK
       670        680        690        700        710        720
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK
       730
KFRTPSFLKK SKKKSDS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35611-1-Acetylation	MNGDSR...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35611-1-Acetylation	MNGDSR...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97051
P35611-1-Acetylation	MNGDSR...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97052
P35611-1-Acetylation	MNGDSR...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97053
P35611-1-unknown	MNGDSR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66372
P35611-1-unknown	MNGDSR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66373
P35611-1-unknown	MNGDSR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66374
P35611-30-unknown	ENNPEY...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1802
P35611-30-unknown	ENNPEY...	30		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137505
P35611-30-unknown	ENNPEY...	30		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137506
P35611-30-unknown	ENNPEY...	30		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137507
P35611-209-unknown	RGSTNL...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1806
P35611-209-unknown	RGSTNL...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146865
P35611-209-unknown	RGSTNL...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146866
P35611-209-unknown	RGSTNL...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146867
P35611-480-	TSTSAV...	480			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35611-480-unknown	TSTSAV...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182680
P35611-480-unknown	TSTSAV...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182682
P35611-480-unknown	TSTSAV...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182681
P35611-501-unknown	EMRNKI...	501		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438069
P35611-501-unknown	EMRNKI...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199716
P35611-501-unknown	EMRNKI...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199718
P35611-501-unknown	EMRNKI...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199717
P35611-534-unknown	VQGELV...	534		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172752
P35611-534-unknown	VQGELV...	534		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172751
P35611-534-	VQGELV...	534			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35611-558-	TTGPNP...	558			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35611-558-unknown	TTGPNP...	558		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182686
P35611-558-unknown	TTGPNP...	558		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182684
P35611-558-unknown	TTGPNP...	558		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182685
P35611-634-	AATFKP...	634			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35611-634-	AATFKP...	634			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P35611-634-unknown	AATFKP...	634		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1810
P35611-634-unknown	AATFKP...	634		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155467
P35611-637-unknown	FKPTLP...	637		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165597
P35611-637-	FKPTLP...	637			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P35611-637-	FKPTLP...	637			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FDRVDE	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1802
...FDRVDE	29	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120480
...FDRVDE	29	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120481
...FDRVDE	29	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120482
...SDSIAY	137	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421918
...SDSIAY	137	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154810
...SDSIAY	137	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154811
...SDSIAY	137	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154812
...GDIVDR	208	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1806
...GDIVDR	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130196
...GDIVDR	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130197
...GDIVDR	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130198
...PAGAAV	247	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426700
...GDDSDA	633	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1810
...GDDSDA	633	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138901
...ADPGSD	707	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424143
...KKSDS	737		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKSDS	737	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKSDS	737	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61991
...KKSDS	737		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	29	RVDE.\|.ENNP	inferred from experiment	unknown	MEROPS	Mulder GJ	van de Water B et al.:Cleavage of the actin-capping p... (C14.003)	10823823,
CASP3_HUMAN	208	IVDR.\|.RGST	inferred from experiment	unknown	MEROPS	Mulder GJ	van de Water B et al.:Cleavage of the actin-capping p... (C14.003)	10823823,
CASP3_HUMAN	633	DSDA.\|.AATF	inferred from experiment	unknown	MEROPS	Mulder GJ	van de Water B et al.:Cleavage of the actin-capping p... (C14.003)	10823823,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)