P35612: Beta-adducin

General Information

Protein names	- Beta-adducin - Erythrocyte adducin subunit beta
Gene names	ADD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35612

9 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Beta-adducin - Isoform 3 of Beta-adducin - Isoform 4 of Beta-adducin - Isoform 5 of Beta-adducin - Isoform 6 of Beta-adducin - Isoform 7 of Beta-adducin - Isoform 8 of Beta-adducin - Isoform 9 of Beta-adducin

Sequence View

        10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES         10         20         30         40         50         60
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS
        70         80         90        100        110        120
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT
       130        140        150        160        170        180
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV
       190        200        210        220        230        240
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK
       250        260        270        280        290        300
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
       310        320        330        340        350        360
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL
       370        380        390        400        410        420
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR
       430        440        450        460        470        480
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE
       490        500        510        520        530        540
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK
       550        560        570        580        590        600
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
       610        620        630        640        650        660
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE
       670        680        690        700        710        720
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK

KEKVES

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35612-1-unknown	MSEETV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66376
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66377
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66378
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66379
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66380
P35612-1-unknown	MSEETV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66381
P35612-2-acetylation	SEETVP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P35612-2-acetylation	SEETVP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162443
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162444
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162445
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162446
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162447
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162448
P35612-2-acetylation	SEETVP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162442
P35612-406-	AFVFEE...	406			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35612-406-unknown	AFVFEE...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182689
P35612-406-unknown	AFVFEE...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182690
P35612-406-unknown	AFVFEE...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182691
P35612-406-unknown	AFVFEE...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182688
P35612-408-	VFEEDG...	408			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35612-408-unknown	VFEEDG...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182694
P35612-408-unknown	VFEEDG...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182695
P35612-408-unknown	VFEEDG...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182696
P35612-408-unknown	VFEEDG...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182693
P35612-552-acetylation	TVPNPF...	552	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P35612-552-acetylation	TVPNPF...	552	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182698
P35612-552-acetylation	TVPNPF...	552	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182699
P35612-552-acetylation	TVPNPF...	552	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182700
P35612-552-acetylation	TVPNPF...	552	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182701
P35612-646-	GVVVNG...	646			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35612-651-	GREEEQ...	651			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSVYRL	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475338
...SSVYRL	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412681
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154887
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154888
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154889
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154890
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154891
...SSVYRL	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154886
...VRCIIH	226	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475446
...VRCIIH	226	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412357
...KLELDG	580	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475973
...KLELDG	580	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414546
...EKVES	726	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)