P35998: 26S proteasome regulatory subunit 7

General Information

Protein names	- 26S proteasome regulatory subunit 7 - 26S proteasome AAA-ATPase subunit RPT1 - Proteasome 26S subunit ATPase 2 - Protein MSS1
Gene names	PSMC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35998

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN
        70         80         90        100        110        120
ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK
       130        140        150        160        170        180
FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC
       190        200        210        220        230        240
KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV
       250        260        270        280        290        300
IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
       310        320        330        340        350        360
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR
       370        380        390        400        410        420
SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY
       430
AKFSATPRYM TYN

Isoforms

- Isoform 2 of 26S proteasome regulatory subunit 7

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35998-2-unknown	PDYLGA...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35998-2-unknown	PDYLGA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P35998-2-unknown	PDYLGA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P35998-35-	TYGQST...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35998-64-	GIKESD...	64		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P35998-84-unknown	KQTLQS...	84	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11469
P35998-138-unknown	MRVGVD...	138	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445546

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLAADK	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11469
...SDQVAP	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401724
...SDQVAP	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393027
...YMTYN	433	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	83	AADK.\|.KQTL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)