P36551: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

General Information

Protein names	- Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial - COX - Coprogen oxidase - Coproporphyrinogenase - 1.3.3.3
Gene names	CPOX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36551

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALQLGRLSS GPCWLVARGG CGGPRAWSQC GGGGLRAWSQ RSAAGRVCRP PGPAGTEQSR
        70         80         90        100        110        120
GLGHGSTSRG GPWVGTGLAA ALAGLVGLAT AAFGHVQRAE MLPKTSGTRA TSLGRPEEEE
       130        140        150        160        170        180
DELAHRCSSF MAPPVTDLGE LRRRPGDMKT KMELLILETQ AQVCQALAQV DGGANFSVDR
       190        200        210        220        230        240
WERKEGGGGI SCVLQDGCVF EKAGVSISVV HGNLSEEAAK QMRSRGKVLK TKDGKLPFCA
       250        260        270        280        290        300
MGVSSVIHPK NPHAPTIHFN YRYFEVEEAD GNKQWWFGGG CDLTPTYLNQ EDAVHFHRTL
       310        320        330        340        350        360
KEACDQHGPD LYPKFKKWCD DYFFIAHRGE RRGIGGIFFD DLDSPSKEEV FRFVQSCARA
       370        380        390        400        410        420
VVPSYIPLVK KHCDDSFTPQ EKLWQQLRRG RYVEFNLLYD RGTKFGLFTP GSRIESILMS
       430        440        450
LPLTARWEYM HSPSENSKEA EILEVLRHPR DWVR

Isoforms

- Isoform 2 of Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P36551-89-	ATAAFG...	89		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P36551-89-	ATAAFG...	89		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36551-89-unknown	ATAAFG...	89		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P36551-110-	ATSLGR...	110		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36551-111-unknown	TSLGRP...	111	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36551-111-unknown	TSLGRP...	111	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P36551-111-	TSLGRP...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36551-111-	TSLGRP...	111		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P36551-112-	SLGRPE...	112		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36551-112-	SLGRPE...	112		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P36551-114-	GRPEEE...	114		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P36551-207-unknown	ISVVHG...	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3784

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KAGVSI	206	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3784
	...RDWVR	454	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	206	GVSI.\|.ISVV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)