P38432: Coilin

General Information

Protein names	- Coilin - p80-coilin
Gene names	COIL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P38432

5 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG FSSGAFLGLY
        70         80         90        100        110        120
LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG DINLSLRKAK KRAFQLEEGE
       130        140        150        160        170        180
ETEPDCKYSK KHWKSRENNN NNEKVLDLEP KAVTDQTVSK KNKRKNKATC GTVGDDNEEA
       190        200        210        220        230        240
KRKSPKKKEK CEYKKKAKNP KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS
       250        260        270        280        290        300
KESPSSSSES ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF
       310        320        330        340        350        360
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR GRPGPGLSSQ
       370        380        390        400        410        420
TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN LFSWKGAKGR GMRGRGRGRG
       430        440        450        460        470        480
HPVSCVVNRS TDNQRQQQLN DVVKNSSTII QNPVETPKKD YSLLPLLAAA PQVGEKIAFK
       490        500        510        520        530        540
LLELTSSYSP DVSDYKEGRI LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV
       550        560        570
EYAVTQESKI TVFWKELIDP RLIIESPSNT SSTEPA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P38432-1-unknown	MAASET...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P38432-2-acetylation	AASETV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P38432-126-unknown	CKYSKK...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11478
P38432-152-unknown	AVTDQT...	152		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14106
P38432-177-unknown	NEEAKR...	177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11479

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SLRKAK	109	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460217
...ETEPDC	125	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11478
...DLEPKA	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14106
...TVGDDN	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11479
...STEPA	576		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...STEPA	576		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...STEPA	576	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...STEPA	576		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...STEPA	576		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	125	EPDC.\|.CKYS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	151	EPKA.\|.AVTD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	176	GDDN.\|.NEEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)