P46734: Dual specificity mitogen-activated protein kinase kinase 3
Protein names | - Dual specificity mitogen-activated protein kinase kinase 3 - MAP kinase kinase 3 - MAPKK 3 - 2.7.12.2 {ECO:0000269|PubMed:8622669} - MAPK/ERK kinase 3 - MEK 3 - Stress-activated protein kinase kinase 2 - SAPK kinase 2 - SAPKK-2 - SAPKK2 |
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Gene names | MAP2K3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P46734 |
6
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE
70 80 90 100 110 120
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC
130 140 150 160 170 180
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL
190 200 210 220 230 240
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL
250 260 270 280 290 300
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD
310 320 330 340
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Isoforms
- Isoform 1 of Dual specificity mitogen-activated protein kinase kinase 3 - Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 3Sequence View
10 20 30 40 50 60
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE
70 80 90 100 110 120
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC
130 140 150 160 170 180
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL
190 200 210 220 230 240
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL
250 260 270 280 290 300
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD
310 320 330 340
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
10 20 30 40 50 60
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE
70 80 90 100 110 120
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC
130 140 150 160 170 180
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL
190 200 210 220 230 240
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL
250 260 270 280 290 300
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD
310 320 330 340
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Protein Neighborhood
Domains & Features
6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P46734-1-Acetylation | MESPAS... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P46734-1-Acetylation | MESPAS... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P46734-1-Acetylation | MESPAS... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P46734-1-Acetylation | MESPAS... | 1 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P46734-30-unknown | MSKPPA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81425 | |||
P46734-30-unknown | MSKPPA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96851 | |||
P46734-31-acetylation | SKPPAP... | 31 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P46734-31-acetylation | SKPPAP... | 31 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182723 | ||
P46734-31-acetylation | SKPPAP... | 31 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182722 | ||
P46734-31- | SKPPAP... | 31 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P46734-31-unknown | SKPPAP... | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178392 | |||
P46734-31-unknown | SKPPAP... | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178391 | |||
P46734-63-unknown | DLVTIS... | 63 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11535 | |||
P46734-63-unknown | DLVTIS... | 63 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137846 | |||
P46734-63-unknown | DLVTIS... | 63 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140478 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EVEADD | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11535 | |||
...EVEADD | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120848 | |||
...EVEADD | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123605 | |||
...LGEDS | 347 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...LGEDS | 347 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77043 | |||
...LGEDS | 347 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77044 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 62 | EADD.|.DLVT | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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