TopFIND 4.0

P46734: Dual specificity mitogen-activated protein kinase kinase 3

General Information

Protein names
- Dual specificity mitogen-activated protein kinase kinase 3
- MAP kinase kinase 3
- MAPKK 3
- 2.7.12.2 {ECO:0000269|PubMed:8622669}
- MAPK/ERK kinase 3
- MEK 3
- Stress-activated protein kinase kinase 2
- SAPK kinase 2
- SAPKK-2
- SAPKK2
Gene names MAP2K3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P46734

6

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE 
        70         80         90        100        110        120 
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC 
       130        140        150        160        170        180 
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL 
       190        200        210        220        230        240 
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 
       250        260        270        280        290        300 
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
       310        320        330        340    
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

Isoforms

- Isoform 1 of Dual specificity mitogen-activated protein kinase kinase 3 - Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 3

Sequence View

        10         20         30         40         50         60 
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE 
        70         80         90        100        110        120 
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC 
       130        140        150        160        170        180 
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL 
       190        200        210        220        230        240 
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 
       250        260        270        280        290        300 
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
       310        320        330        340    
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS         10         20         30         40         50         60 
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE 
        70         80         90        100        110        120 
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC 
       130        140        150        160        170        180 
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL 
       190        200        210        220        230        240 
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 
       250        260        270        280        290        300 
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
       310        320        330        340    
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)