P46821: Microtubule-associated protein 1B

General Information

Protein names	- Microtubule-associated protein 1B - MAP-1B - MAP1B heavy chain - MAP1 light chain LC1
Gene names	MAP1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46821

9 N-termini

10 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATVVVEATE PEPSGSIANP AASTSPSLSH RFLDSKFYLL VVVGEIVTEE HLRRAIGNIE
        70         80         90        100        110        120
LGIRSWDTNL IECNLDQELK LFVSRHSARF SPEVPGQKIL HHRSDVLETV VLINPSDEAV
       130        140        150        160        170        180
STEVRLMITD AARHKLLVLT GQCFENTGEL ILQSGSFSFQ NFIEIFTDQE IGELLSTTHP
       190        200        210        220        230        240
ANKASLTLFC PEEGDWKNSN LDRHNLQDFI NIKLNSASIL PEMEGLSEFT EYLSESVEVP
       250        260        270        280        290        300
SPFDILEPPT SGGFLKLSKP CCYIFPGGRG DSALFAVNGF NMLINGGSER KSCFWKLIRH
       310        320        330        340        350        360
LDRVDSILLT HIGDDNLPGI NSMLQRKIAE LEEEQSQGST TNSDWMKNLI SPDLGVVFLN
       370        380        390        400        410        420
VPENLKNPEP NIKMKRSIEE ACFTLQYLNK LSMKPEPLFR SVGNTIDPVI LFQKMGVGKL
       430        440        450        460        470        480
EMYVLNPVKS SKEMQYFMQQ WTGTNKDKAE FILPNGQEVD LPISYLTSVS SLIVWHPANP
       490        500        510        520        530        540
AEKIIRVLFP GNSTQYNILE GLEKLKHLDF LKQPLATQKD LTGQVPTPVV KQTKLKQRAD
       550        560        570        580        590        600
SRESLKPAAK PLPSKSVRKE SKEETPEVTK VNHVEKPPKV ESKEKVMVKK DKPIKTETKP
       610        620        630        640        650        660
SVTEKEVPSK EEPSPVKAEV AEKQATDVKP KAAKEKTVKK ETKVKPEDKK EEKEKPKKEV
       670        680        690        700        710        720
AKKEDKTPIK KEEKPKKEEV KKEVKKEIKK EEKKEPKKEV KKETPPKEVK KEVKKEEKKE
       730        740        750        760        770        780
VKKEEKEPKK EIKKLPKDAK KSSTPLSEAK KPAALKPKVP KKEESVKKDS VAAGKPKEKG
       790        800        810        820        830        840
KIKVIKKEGK AAEAVAAAVG TGATTAAVMA AAGIAAIGPA KELEAERSLM SSPEDLTKDF
       850        860        870        880        890        900
EELKAEEVDV TKDIKPQLEL IEDEEKLKET EPVEAYVIQK EREVTKGPAE SPDEGITTTE
       910        920        930        940        950        960
GEGECEQTPE ELEPVEKQGV DDIEKFEDEG AGFEESSETG DYEEKAETEE AEEPEEDGEE
       970        980        990       1000       1010       1020
HVCVSASKHS PTEDEESAKA EADAYIREKR ESVASGDDRA EEDMDEAIEK GEAEQSEEEA
      1030       1040       1050       1060       1070       1080
DEEDKAEDAR EEEYEPEKME AEDYVMAVVD KAAEAGGAEE QYGFLTTPTK QLGAQSPGRE
      1090       1100       1110       1120       1130       1140
PASSIHDETL PGGSESEATA SDEENREDQP EEFTATSGYT QSTIEISSEP TPMDEMSTPR
      1150       1160       1170       1180       1190       1200
DVMSDETNNE ETESPSQEFV NITKYESSLY SQEYSKPADV TPLNGFSEGS KTDATDGKDY
      1210       1220       1230       1240       1250       1260
NASASTISPP SSMEEDKFSR SALRDAYCSE VKASTTLDIK DSISAVSSEK VSPSKSPSLS
      1270       1280       1290       1300       1310       1320
PSPPSPLEKT PLGERSVNFS LTPNEIKVSA EAEVAPVSPE VTQEVVEEHC ASPEDKTLEV
      1330       1340       1350       1360       1370       1380
VSPSQSVTGS AGHTPYYQSP TDEKSSHLPT EVIEKPPAVP VSFEFSDAKD ENERASVSPM
      1390       1400       1410       1420       1430       1440
DEPVPDSESP IEKVLSPLRS PPLIGSESAY ESFLSADDKA SGRGAESPFE EKSGKQGSPD
      1450       1460       1470       1480       1490       1500
QVSPVSEMTS TSLYQDKQEG KSTDFAPIKE DFGQEKKTDD VEAMSSQPAL ALDERKLGDV
      1510       1520       1530       1540       1550       1560
SPTQIDVSQF GSFKEDTKMS ISEGTVSDKS ATPVDEGVAE DTYSHMEGVA SVSTASVATS
      1570       1580       1590       1600       1610       1620
SFPEPTTDDV SPSLHAEVGS PHSTEVDDSL SVSVVQTPTT FQETEMSPSK EECPRPMSIS
      1630       1640       1650       1660       1670       1680
PPDFSPKTAK SRTPVQDHRS EQSSMSIEFG QESPEQSLAM DFSRQSPDHP TVGAGVLHIT
      1690       1700       1710       1720       1730       1740
ENGPTEVDYS PSDMQDSSLS HKIPPMEEPS YTQDNDLSEL ISVSQVEASP STSSAHTPSQ
      1750       1760       1770       1780       1790       1800
IASPLQEDTL SDVAPPRDMS LYASLTSEKV QSLEGEKLSP KSDISPLTPR ESSPLYSPTF
      1810       1820       1830       1840       1850       1860
SDSTSAVKEK TATCHSSSSP PIDAASAEPY GFRASVLFDT MQHHLALNRD LSTPGLEKDS
      1870       1880       1890       1900       1910       1920
GGKTPGDFSY AYQKPEETTR SPDEEDYDYE SYEKTTRTSD VGGYYYEKIE RTTKSPSDSG
      1930       1940       1950       1960       1970       1980
YSYETIGKTT KTPEDGDYSY EIIEKTTRTP EEGGYSYDIS EKTTSPPEVS GYSYEKTERS
      1990       2000       2010       2020       2030       2040
RRLLDDISNG YDDSEDGGHT LGDPSYSYET TEKITSFPES EGYSYETSTK TTRTPDTSTY
      2050       2060       2070       2080       2090       2100
CYETAEKITR TPQASTYSYE TSDLCYTAEK KSPSEARQDV DLCLVSSCEY KHPKTELSPS
      2110       2120       2130       2140       2150       2160
FINPNPLEWF ASEEPTEESE KPLTQSGGAP PPPGGKQQGR QCDETPPTSV SESAPSQTDS
      2170       2180       2190       2200       2210       2220
DVPPETEECP SITADANIDS EDESETIPTD KTVTYKHMDP PPAPVQDRSP SPRHPDVSMV
      2230       2240       2250       2260       2270       2280
DPEALAIEQN LGKALKKDLK EKTKTKKPGT KTKSSSPVKK SDGKSKPLAA SPKPAGLKES
      2290       2300       2310       2320       2330       2340
SDKVSRVASP KKKESVEKAA KPTTTPEVKA ARGEEKDKET KNAANASASK SAKTATAGPG
      2350       2360       2370       2380       2390       2400
TTKTTKSSAV PPGLPVYLDL CYIPNHSNSK NVDVEFFKRV RSSYYVVSGN DPAAEEPSRA
      2410       2420       2430       2440       2450       2460
VLDALLEGKA QWGSNMQVTL IPTHDSEVMR EWYQETHEKQ QDLNIMVLAS SSTVVMQDES

FPACKIEL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 10 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P46821-2-unknown	MATVVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P46821-2-Acetylation	ATVVVE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P46821-127-unknown	MITDAA...	127		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423416
P46821-810-unknown	AAAGIA...	810		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14139
P46821-812-unknown	AGIAAI...	812		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11545
P46821-1408-unknown	SAYESF...	1408		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11546
P46821-2207-unknown	DRSPSP...	2207		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P46821-2269-unknown	AASPKP...	2269		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14140
P46821-2278-unknown	KESSDK...	2278		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14141

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAVSTE	122	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426312
...KKEEKE	653	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423444
...EEKKEP	695	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423416
...TAAVMA	809	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14139
...AVMAAA	811	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11545
...LIGSES	1407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11546
...PAPVQD	2206	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KSKPLA	2268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14140
...KPAGLK	2277	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14141
...CKIEL	2468	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	809	AVMA.\|.AAAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	811	MAAA.\|.AGIA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	1407	GSES.\|.SAYE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	2268	KPLA.\|.AASP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	2277	AGLK.\|.KESS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)