P46934: E3 ubiquitin-protein ligase NEDD4

General Information

Protein names	- E3 ubiquitin-protein ligase NEDD4 - 2.3.2.26 {ECO:0000269\|PubMed:17218260, ECO:0000269\|PubMed:21399620} - Cell proliferation-inducing gene 53 protein - HECT-type E3 ubiquitin transferase NEDD4 - Neural precursor cell expressed developmentally down-regulated protein 4 - NEDD-4
Gene names	NEDD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46934

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase NEDD4 - Isoform 3 of E3 ubiquitin-protein ligase NEDD4 - Isoform 4 of E3 ubiquitin-protein ligase NEDD4

Sequence View

        10         20         30         40         50         60
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP
        70         80         90        100        110        120
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD
       130        140        150        160        170        180
GIYSSAVVDN ELNAVNDGHL VSSPAICSGS LSNFSTSDNG SYSSNGSDFG SCASITSGGS
       190        200        210        220        230        240
YTNSVISDSS SYTFPPSDDT FLGGNLPSDS TSNRSVPNRN TTPCEIFSRS TSTDPFVQDD
       250        260        270        280        290        300
LEHGLEIMKL PVSRNTKIPL KRYSSLVIFP RSPSTTRPTS PTSLCTLLSK GSYQTSHQFI
       310        320        330        340        350        360
ISPSEIAHNE DGTSAKGFLS TAVNGLRLSK TICTPGEVRD IRPLHRKGSL QKKIVLSNNT
       370        380        390        400        410        420
PRQTVCEKSS EGYSCVSVHF TQRKAATLDC ETTNGDCKPE MSEIKLNSDS EYIKLMHRTS
       430        440        450        460        470        480
ACLPSSQNVD CQININGELE RPHSQMNKNH GILRRSISLG GAYPNISCLS SLKHNCSKGG
       490        500        510        520        530        540
PSQLLIKFAS GNEGKVDNLS RDSNRDCTNE LSNSCKTRDD FLGQVDVPLY PLPTENPRLE
       550        560        570        580        590        600
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKTSGSEDDN AEQAEELEPG WVVLDQPDAA
       610        620        630        640        650        660
CHLQQQQEPS PLPPGWEERQ DILGRTYYVN HESRRTQWKR PTPQDNLTDA ENGNIQLQAQ
       670        680        690        700        710        720
RAFTTRRQIS EETESVDNRE SSENWEIIRE DEATMYSNQA FPSPPPSSNL DVPTHLAEEL
       730        740        750        760        770        780
NARLTIFGNS AVSQPASSSN HSSRRGSLQA YTFEEQPTLP VLLPTSSGLP PGWEEKQDER
       790        800        810        820        830        840
GRSYYVDHNS RTTTWTKPTV QATVETSQLT SSQSSAGPQS QASTSDSGQQ VTQPSEIEQG
       850        860        870        880        890        900
FLPKGWEVRH APNGRPFFID HNTKTTTWED PRLKIPAHLR GKTSLDTSND LGPLPPGWEE
       910        920        930        940        950        960
RTHTDGRIFY INHNIKRTQW EDPRLENVAI TGPAVPYSRD YKRKYEFFRR KLKKQNDIPN
       970        980        990       1000       1010       1020
KFEMKLRRAT VLEDSYRRIM GVKRADFLKA RLWIEFDGEK GLDYGGVARE WFFLISKEMF
      1030       1040       1050       1060       1070       1080
NPYYGLFEYS ATDNYTLQIN PNSGLCNEDH LSYFKFIGRV AGMAVYHGKL LDGFFIRPFY
      1090       1100       1110       1120       1130       1140
KMMLHKPITL HDMESVDSEY YNSLRWILEN DPTELDLRFI IDEELFGQTH QHELKNGGSE
      1150       1160       1170       1180       1190       1200
IVVTNKNKKE YIYLVIQWRF VNRIQKQMAA FKEGFFELIP QDLIKIFDEN ELELLMCGLG
      1210       1220       1230       1240       1250       1260
DVDVNDWREH TKYKNGYSAN HQVIQWFWKA VLMMDSEKRI RLLQFVTGTS RVPMNGFAEL
      1270       1280       1290       1300       1310
YGSNGPQSFT VEQWGTPEKL PRAHTCFNRL DLPPYESFEE LWDKLQMAIE NTQGFDGVD         10         20         30         40         50         60
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP
        70         80         90        100        110        120
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD
       130        140        150        160        170        180
GIYSSAVVDN ELNAVNDGHL VSSPAICSGS LSNFSTSDNG SYSSNGSDFG SCASITSGGS
       190        200        210        220        230        240
YTNSVISDSS SYTFPPSDDT FLGGNLPSDS TSNRSVPNRN TTPCEIFSRS TSTDPFVQDD
       250        260        270        280        290        300
LEHGLEIMKL PVSRNTKIPL KRYSSLVIFP RSPSTTRPTS PTSLCTLLSK GSYQTSHQFI
       310        320        330        340        350        360
ISPSEIAHNE DGTSAKGFLS TAVNGLRLSK TICTPGEVRD IRPLHRKGSL QKKIVLSNNT
       370        380        390        400        410        420
PRQTVCEKSS EGYSCVSVHF TQRKAATLDC ETTNGDCKPE MSEIKLNSDS EYIKLMHRTS
       430        440        450        460        470        480
ACLPSSQNVD CQININGELE RPHSQMNKNH GILRRSISLG GAYPNISCLS SLKHNCSKGG
       490        500        510        520        530        540
PSQLLIKFAS GNEGKVDNLS RDSNRDCTNE LSNSCKTRDD FLGQVDVPLY PLPTENPRLE
       550        560        570        580        590        600
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKTSGSEDDN AEQAEELEPG WVVLDQPDAA
       610        620        630        640        650        660
CHLQQQQEPS PLPPGWEERQ DILGRTYYVN HESRRTQWKR PTPQDNLTDA ENGNIQLQAQ
       670        680        690        700        710        720
RAFTTRRQIS EETESVDNRE SSENWEIIRE DEATMYSNQA FPSPPPSSNL DVPTHLAEEL
       730        740        750        760        770        780
NARLTIFGNS AVSQPASSSN HSSRRGSLQA YTFEEQPTLP VLLPTSSGLP PGWEEKQDER
       790        800        810        820        830        840
GRSYYVDHNS RTTTWTKPTV QATVETSQLT SSQSSAGPQS QASTSDSGQQ VTQPSEIEQG
       850        860        870        880        890        900
FLPKGWEVRH APNGRPFFID HNTKTTTWED PRLKIPAHLR GKTSLDTSND LGPLPPGWEE
       910        920        930        940        950        960
RTHTDGRIFY INHNIKRTQW EDPRLENVAI TGPAVPYSRD YKRKYEFFRR KLKKQNDIPN
       970        980        990       1000       1010       1020
KFEMKLRRAT VLEDSYRRIM GVKRADFLKA RLWIEFDGEK GLDYGGVARE WFFLISKEMF
      1030       1040       1050       1060       1070       1080
NPYYGLFEYS ATDNYTLQIN PNSGLCNEDH LSYFKFIGRV AGMAVYHGKL LDGFFIRPFY
      1090       1100       1110       1120       1130       1140
KMMLHKPITL HDMESVDSEY YNSLRWILEN DPTELDLRFI IDEELFGQTH QHELKNGGSE
      1150       1160       1170       1180       1190       1200
IVVTNKNKKE YIYLVIQWRF VNRIQKQMAA FKEGFFELIP QDLIKIFDEN ELELLMCGLG
      1210       1220       1230       1240       1250       1260
DVDVNDWREH TKYKNGYSAN HQVIQWFWKA VLMMDSEKRI RLLQFVTGTS RVPMNGFAEL
      1270       1280       1290       1300       1310
YGSNGPQSFT VEQWGTPEKL PRAHTCFNRL DLPPYESFEE LWDKLQMAIE NTQGFDGVD         10         20         30         40         50         60
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP
        70         80         90        100        110        120
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD
       130        140        150        160        170        180
GIYSSAVVDN ELNAVNDGHL VSSPAICSGS LSNFSTSDNG SYSSNGSDFG SCASITSGGS
       190        200        210        220        230        240
YTNSVISDSS SYTFPPSDDT FLGGNLPSDS TSNRSVPNRN TTPCEIFSRS TSTDPFVQDD
       250        260        270        280        290        300
LEHGLEIMKL PVSRNTKIPL KRYSSLVIFP RSPSTTRPTS PTSLCTLLSK GSYQTSHQFI
       310        320        330        340        350        360
ISPSEIAHNE DGTSAKGFLS TAVNGLRLSK TICTPGEVRD IRPLHRKGSL QKKIVLSNNT
       370        380        390        400        410        420
PRQTVCEKSS EGYSCVSVHF TQRKAATLDC ETTNGDCKPE MSEIKLNSDS EYIKLMHRTS
       430        440        450        460        470        480
ACLPSSQNVD CQININGELE RPHSQMNKNH GILRRSISLG GAYPNISCLS SLKHNCSKGG
       490        500        510        520        530        540
PSQLLIKFAS GNEGKVDNLS RDSNRDCTNE LSNSCKTRDD FLGQVDVPLY PLPTENPRLE
       550        560        570        580        590        600
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKTSGSEDDN AEQAEELEPG WVVLDQPDAA
       610        620        630        640        650        660
CHLQQQQEPS PLPPGWEERQ DILGRTYYVN HESRRTQWKR PTPQDNLTDA ENGNIQLQAQ
       670        680        690        700        710        720
RAFTTRRQIS EETESVDNRE SSENWEIIRE DEATMYSNQA FPSPPPSSNL DVPTHLAEEL
       730        740        750        760        770        780
NARLTIFGNS AVSQPASSSN HSSRRGSLQA YTFEEQPTLP VLLPTSSGLP PGWEEKQDER
       790        800        810        820        830        840
GRSYYVDHNS RTTTWTKPTV QATVETSQLT SSQSSAGPQS QASTSDSGQQ VTQPSEIEQG
       850        860        870        880        890        900
FLPKGWEVRH APNGRPFFID HNTKTTTWED PRLKIPAHLR GKTSLDTSND LGPLPPGWEE
       910        920        930        940        950        960
RTHTDGRIFY INHNIKRTQW EDPRLENVAI TGPAVPYSRD YKRKYEFFRR KLKKQNDIPN
       970        980        990       1000       1010       1020
KFEMKLRRAT VLEDSYRRIM GVKRADFLKA RLWIEFDGEK GLDYGGVARE WFFLISKEMF
      1030       1040       1050       1060       1070       1080
NPYYGLFEYS ATDNYTLQIN PNSGLCNEDH LSYFKFIGRV AGMAVYHGKL LDGFFIRPFY
      1090       1100       1110       1120       1130       1140
KMMLHKPITL HDMESVDSEY YNSLRWILEN DPTELDLRFI IDEELFGQTH QHELKNGGSE
      1150       1160       1170       1180       1190       1200
IVVTNKNKKE YIYLVIQWRF VNRIQKQMAA FKEGFFELIP QDLIKIFDEN ELELLMCGLG
      1210       1220       1230       1240       1250       1260
DVDVNDWREH TKYKNGYSAN HQVIQWFWKA VLMMDSEKRI RLLQFVTGTS RVPMNGFAEL
      1270       1280       1290       1300       1310
YGSNGPQSFT VEQWGTPEKL PRAHTCFNRL DLPPYESFEE LWDKLQMAIE NTQGFDGVD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46934-1-unknown	MAQSLR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46934-1-unknown	MAQSLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82564
P46934-1-unknown	MAQSLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82565
P46934-2-acetylation	AQSLRL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P46934-2-acetylation	AQSLRL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182725
P46934-2-acetylation	AQSLRL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182726
P46934-102-acetylation	SSNVLA...	102	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P46934-102-acetylation	SSNVLA...	102	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163277
P46934-102-acetylation	SSNVLA...	102	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163278
P46934-527-unknown	VPLYPL...	527		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1854
P46934-527-unknown	VPLYPL...	527		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153713
P46934-527-unknown	VPLYPL...	527		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199780
P46934-700-unknown	AFPSPP...	700		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167399
P46934-700-unknown	AFPSPP...	700		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167400
P46934-700-unknown	AFPSPP...	700		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167401
P46934-700-	AFPSPP...	700			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46934-700-	AFPSPP...	700			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P46934-700-	AFPSPP...	700			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P46934-731-unknown	AVSQPA...	731		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167403
P46934-731-unknown	AVSQPA...	731		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167404
P46934-731-unknown	AVSQPA...	731		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167405
P46934-731-	AVSQPA...	731			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46934-731-	AVSQPA...	731			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P46934-731-	AVSQPA...	731			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGQVDV	526	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1854
...LGQVDV	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137136
...FDGVD	1319	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FDGVD	1319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78184
...FDGVD	1319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78183
...FDGVD	1319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78182

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	526	QVDV.\|.VPLY	inferred from experiment	unknown	MEROPS	Kumar S	Harvey KF et al.:Caspase-mediated cleavage of th... (C14.003)	9593687,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)