P47712: Cytosolic phospholipase A2

General Information

Protein names	- Cytosolic phospholipase A2 - cPLA2 - Phospholipase A2 group IVA - Phospholipase A2 - 3.1.1.4 - Phosphatidylcholine 2-acylhydrolase - Lysophospholipase - 3.1.1.5
Gene names	PLA2G4A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P47712

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGAFGDMLD TPDPYVELFI STTPDSRKRT
        70         80         90        100        110        120
RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE TLGTATFTVS SMKVGEKKEV
       130        140        150        160        170        180
PFIFNQVTEM VLEMSLEVCS CPDLRFSMAL CDQEKTFRQQ RKEHIRESMK KLLGPKNSEG
       190        200        210        220        230        240
LHSARDVPVV AILGSGGGFR AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH
       250        260        270        280        290        300
PDFPEKGPEE INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG
       310        320        330        340        350        360
ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS PYEIGMAKYG
       370        380        390        400        410        420
TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL FNRVLGVSGS QSRGSTMEEE
       430        440        450        460        470        480
LENITTKHIV SNDSSDSDDE SHEPKGTENE DAGSDYQSDN QASWIHRMIM ALVSDSALFN
       490        500        510        520        530        540
TREGRAGKVH NFMLGLNLNT SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV
       550        560        570        580        590        600
KSKKIHVVDS GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN
       610        620        630        640        650        660
KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY RAPGVPRETE
       670        680        690        700        710        720
EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN TLNNIDVIKE AMVESIEYRR
       730        740
QNPSRCSVSL SNVEARRFFN KEFLSKPKA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P47712-1-unknown	MSFIDP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P47712-460-unknown	NQASWI...	460	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1227
P47712-523-unknown	AAVADP...	523	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3075
P47712-523-unknown	AAVADP...	523	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1857
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P47712-523-	AAVADP...	523		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P47712-524-	AVADPD...	524		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P47712-524-	AVADPD...	524		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P47712-524-	AVADPD...	524		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P47712-524-	AVADPD...	524		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DYQSDN	459	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1227
...DDELDA	522	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3075
...DDELDA	522	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1857
...SKPKA	749	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SKPKA	749		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SKPKA	749		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	459	QSDN.\|.NQAS	inferred from experiment	unknown	MEROPS	Adam-Klages S	Luschen S et al.:Cleavage of human cytosolic pho... (C14.001)	9875225,
CASP8_HUMAN	522	ELDA.\|.AAVA	inferred from experiment	unknown	MEROPS	Adam-Klages S	Luschen S et al.:Cleavage of human cytosolic pho... (C14.001)	9875225,
CASP3_HUMAN	522	ELDA.\|.AAVA	inferred from experiment	unknown	MEROPS	Kronke M	Adam-Klages S et al.:Caspase-mediated inhibition of ... (C14.003)	9820550,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)