P49023: Paxillin

General Information

Protein names	- Paxillin
Gene names	PXN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49023

13 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Alpha of Paxillin - Isoform Gamma of Paxillin - Isoform 4 of Paxillin

Sequence View

        10         20         30         40         50         60
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
        70         80         90        100        110        120
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
       130        140        150        160        170        180
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
       190        200        210        220        230        240
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
       250        260        270        280        290        300
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG
       310        320        330        340        350        360
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA
       370        380        390        400        410        420
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC
       430        440        450        460        470        480
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA
       490        500        510        520        530        540
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK
       550        560        570        580        590
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C         10         20         30         40         50         60
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
        70         80         90        100        110        120
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
       130        140        150        160        170        180
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
       190        200        210        220        230        240
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
       250        260        270        280        290        300
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG
       310        320        330        340        350        360
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA
       370        380        390        400        410        420
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC
       430        440        450        460        470        480
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA
       490        500        510        520        530        540
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK
       550        560        570        580        590
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C         10         20         30         40         50         60
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
        70         80         90        100        110        120
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
       130        140        150        160        170        180
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
       190        200        210        220        230        240
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
       250        260        270        280        290        300
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG
       310        320        330        340        350        360
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA
       370        380        390        400        410        420
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC
       430        440        450        460        470        480
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA
       490        500        510        520        530        540
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK
       550        560        570        580        590
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49023-1-unknown	MDDLDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84401
P49023-1-unknown	MDDLDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84402
P49023-1-Acetylation	MDDLDA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49023-1-Acetylation	MDDLDA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104594
P49023-1-Acetylation	MDDLDA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104595
P49023-6-unknown	ALLADL...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1859
P49023-6-unknown	ALLADL...	6			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49023-6-unknown	ALLADL...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161918
P49023-6-unknown	ALLADL...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161919
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49023-6-	ALLADL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49023-103-unknown	SVGSPC...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1860
P49023-103-unknown	SVGSPC...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142540
P49023-103-unknown	SVGSPC...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142541
P49023-134-unknown	MSTSLG...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84403
P49023-134-unknown	MSTSLG...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105893
P49023-134-unknown	MSTSLG...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105894
P49023-137-unknown	SLGSNL...	137		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174225
P49023-137-unknown	SLGSNL...	137		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174226
P49023-137-unknown	SLGSNL...	137		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174227
P49023-137-	SLGSNL...	137			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49023-147-unknown	RLLLEL...	147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1863
P49023-147-unknown	RLLLEL...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136467
P49023-147-unknown	RLLLEL...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144593
P49023-147-unknown	RLLLEL...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144594
P49023-166-unknown	EANSSP...	166		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1867
P49023-166-unknown	EANSSP...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137778
P49023-166-unknown	EANSSP...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145365
P49023-166-unknown	EANSSP...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145366
P49023-223-unknown	ELESSV...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1871
P49023-223-unknown	ELESSV...	223		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141811
P49023-223-unknown	ELESSV...	223		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147477
P49023-223-unknown	ELESSV...	223		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147478
P49023-336-unknown	SMLGSL...	336		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1875
P49023-336-unknown	SMLGSL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145496
P49023-336-unknown	SMLGSL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149921
P49023-336-unknown	SMLGSL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150934
P49023-336-	SMLGSL...	336			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49023-336-	SMLGSL...	336			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MDDLDA	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1859
...SNPQDS	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1860
...SNPQDS	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125735
...SNPQDS	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125736
...LSELDR	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1863
...LSELDR	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127860
...LSELDR	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127861
...GFPADE	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1867
...GFPADE	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120778
...GFPADE	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128658
...GFPADE	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128659
...ESLLDE	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1871
...ESLLDE	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124992
...ESLLDE	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130827
...ESLLDE	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130828
...GSQLDS	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1875
...GSQLDS	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128792
...GSQLDS	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133312
...GSQLDS	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134336
...LKLFC	591	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LKLFC	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80021
...LKLFC	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80019
...LKLFC	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80020

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	5	DLDA.\|.ALLA	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,
CASP3_HUMAN	102	PQDS.\|.SVGS	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,
CASP3_HUMAN	146	ELDR.\|.RLLL	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,
CASP3_HUMAN	165	PADE.\|.EANS	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,
CASP3_HUMAN	222	LLDE.\|.ELES	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,
CASP3_HUMAN	335	QLDS.\|.SMLG	inferred from experiment	unknown	MEROPS	Mushinski JF	Chay KO et al.:Linkage of caspase-mediated deg... (C14.003)	11825902,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)